Gestational Trophoblastic Disease Market to Observe Strong Development by 2018

The global gestational trophoblastic disease market is expected to grow significantly at a healthy CAGR during the forecast period from 2018 to 2023. Gestational trophoblastic disease (GTD) comprises a group of interrelated ailments that arise from the placental trophoblastic tissue. This can occur after normal or abnormal fertilization and is characterized by a distinct tumor marker, β-subunit of human chorionic gonadotrophin (β HCG).

Increase in risk factors affecting this spectrum of disease is expected to drive the growth of the market. These risk factors include high maternal age, the rise in ectopic pregnancies and excessive smoking. According to the American Lung Association, cigarette smoking kills an estimated 201,770 women annually in the US. Also, the increase in innovations in the field of oncology in anticipated to contribute significantly to the growth in this market. For instance, as on 11th October 2018, Bristol-Myers Squibb Company and Compugen Ltd. announced a clinical collaboration to evaluate therapeutic regimen in advanced solid tumors. Compugen Ltd., being a therapeutic discovery company, consists of immuno-oncology programs against novel drug targets in the areas of unmet medical needs in various cancer types and patient populations.

Moreover, high risk of recurrence of the tumors, even after single or multi-agent chemotherapy and difficulty in diagnosing the types of hydatidiform moles may hamper the market growth. Also, mismanagement of the disease with unclear or no guidelines in different regions may curb the growth of gestational trophoblastic disease during the assessment period. Some of the forms of the gestational trophoblastic disease start to show symptoms only after it reaches stage III. At this stage, it might have already spread to other parts of the body. According to the American Society of Clinical Oncology (ASCO), about 35% of women with placental-site trophoblastic tumor have had the cancer spread before it was diagnosed.

Competitive Landscape:

Teva Pharmaceutical Industries Ltd., Hikma Pharmaceuticals PLC, Pfizer Inc., Bristol-Myers Squibb Company, Antares Pharma, Mylan N.V., Novartis AG, BP Pharmaceuticals Laboratories Company, Fresenius Kabi AG, Accord Healthcare, Inc., Eli Lilly and Company, Sanofi, Bayer AG, Amgen Inc. and Merck are some of the key players in the global gestational trophoblastic disease market.

Segmentation:The global gestational trophoblastic disease market has been segmented into type, treatment, and end user.

The market, on the basis of type, has been segmented into a hydatidiform mole, choriocarcinoma, placental-site trophoblastic tumor, epithelioid trophoblastic tumor, and others.

The market, based on the hydatidiform mole, has been further segmented into a complete, partial and invasive mole. The market, based on hydatidiform mole is expected to hold the largest share as it is the most common form of the gestational trophoblastic disease,  whereas choriocarcinoma is projected to be the fastest-growing market as the incidence rate of this form is increasing steadily according to a journal published by National Center for Biotechnology Information.

The market, by treatment, has been segmented into surgery, chemotherapy, suction dilation and curettage (D&C), and radiation therapy.

The market, based on surgery, has been sub-segmented into an abdominal hysterectomy and vaginal hysterectomy.

The market, by end user, has been segmented into hospital and clinics, diagnostic centers, and others.

The market has been segmented regionally into the Americas, Europe, Asia-Pacific, and the Middle East & Africa. The gestational trophoblastic disease market in the Americas has further been segmented into North America and South America, with the North American market divided into the US and Canada.

The European gestational trophoblastic disease market has been segmented into Western Europe and Eastern Europe. Western Europe has further been classified as Germany, France, the UK, Italy, Spain, and the rest of Western Europe.

The gestational trophoblastic disease market in Asia-Pacific has been segmented into Japan, China, India, South Korea, Australia, and the rest of Asia-Pacific. The gestational trophoblastic disease market in the Middle East & Africa has been segmented into the Middle East and Africa.

Regional Market Summary

Geographically, the Americas is projected to dominate the global gestational trophoblastic disease market owing to an increased awareness about the disease and favorable reimbursement scenario. Also, the rise in a number of marketing approvals, as well as product approvals in the field of oncology drive the market growth.

Europe is expected to hold the second largest position in the global gestational trophoblastic disease market. The market growth in this region is attributed to the availability of funds for research and an increasing healthcare expenditure.

Asia-Pacific is anticipated to be the fastest growing region in the market due to the presence of a huge patient population and continuously developing economies.

On the other hand, the Middle East and Africa has the least share of the market. This is due to the stringent government regulations and lack of technical expertise in the treatment of the disease.

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Colposcopy Market to Observe Strong Development by 2018

A colposcope is basically a surgical instrument similar to an electric microscope with a source of light that allows gynecologists to examine the vagina and cervix more clearly and under proper magnification. The rising prevalence of cervical cancer around the globe is the primary factor driving the growth of the colposcopy market.

The Global Colposcopy Market is expected to gain prominence over the forecast period (2018–2023). It is estimated that the global colposcopy market is expected to register a CAGR of ~6.8% during the forecast period, 2018–2023.

For instance, according to the World Health Organization (WHO) in 2017, cervical cancer is the second most reason for the death of women worldwide. Currently, awareness programmes are conducted by numerous NGOs focusing on health-related issues in women such as cervical cancer which will increase the demand for colposcopes.

Despite these drivers, factors such as high installation cost of this device and lack of skilled clinical users to operate colposcopes are likely to restrain the growth of the market.

Company Profiles            

• Carl Zeiss
• Olympus Corporation
• Danaher Corporation
• Philips Healthcare
• CooperSurgical
• McKesson Corporation
• DYSIS Medical
• Atmos
• Alliton
• Seliga Microscopes
• Karl Kaps
• Bovie Medical

Segmentation

The global colposcopy market is segmented on the basis of instrument type, instrument portability, application, and end-users.

On the basis of instrument type, the market is classified into optical colposcopes and digital colposcopes.

On the basis of instrument portability, the market is classified into portable, fixed, and handheld.

On the basis of application, the market is classified as cervical cancer screening, physical examinations, and others.

On the basis of magnification type, the market is classified into fixed magnification and variable magnification

On the basis of end-user, the market is classified into hospitals, clinics, diagnostic centers, and others.

Geographically, the market has been segmented into the Americas, Europe, Asia-Pacific, and the Middle East and Africa. The American colposcopy market is further segmented into North America and South America. North America is further classified as the US and Canada.

The European colposcopy market is segmented into Western Europe and Eastern Europe. Western Europe is further classified as Germany, France, the UK, Italy, Spain, and the Rest of Western Europe. 

The colposcopy market in Asia-Pacific is segmented into Japan, China, India, the Republic of Korea, Australia, and the Rest of Asia-Pacific.

The Middle Eastern and African colposcopy market is segmented into the Middle East and Africa.

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Regional Market Summary

Asia-Pacific is the fastest growing region in the market owing to the increasing cases of cervical cancer in the region, growing demand for cervical cancer screening, and rising healthcare expenditure in Asian countries. Additionally, according to a study published in the World Health Organization (WHO) in 2017, every year cervical cancer kills more than 250000 women, and 85% of these deaths occur in low- and middle-income countries. Furthermore, the rapid development of economies and increasing healthcare expenditure have fuelled the growth of the market.

The Americas is likely to dominate the global colposcopy market owing to technological advancements in colposcopes such as high-quality video and improved accuracy in detection. For instance, the American Cancer Society in 2018, estimated about 13,240 new cases of invasive cervical cancer to be diagnosed in the US with nearly 4,170 women dying from cervical cancer. Furthermore, continuous development of advanced colposcopy by manufacturers in the region contributes to the market growth.

Europe is likely to hold the second position in the global colposcopy market. It is expected that the favorable reimbursement scenario is responsible for the ambient growth in this region. Additionally, according to the Cancer Research UK in 2017, more than 3000 new cases of cervical cancer are diagnosed in the UK each year.  

The Middle East and Africa accounts for the lowest market share in the global colposcopy market owing to the lack of awareness regarding cervical cancer in the MEA region.

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Bariatric Surgery Devices Market 2018–By Identifying the Key Market Segments and Key players holding market share

Market Scenario

The bariatric surgery devices market is expected to register a CAGR of 5.5% during the forecast period reaching almost 2200 USD million. Bariatric surgery is a procedure used for weight loss in which stomach size is reduced either by using a gastric band, by cutting a small portion of the stomach, or by resecting small intestine into the stomach. The global bariatric surgery devices market is majorly driven by increasing technical advanced devices, increasing number of regulatory approvals, rising cases of obesity, the high prevalence of diseases related to obesity and growing penetration of key market players. Furthermore, raising awareness of healthcare, favorable reimbursement policies, increasing innovations in research and development of medical devices, as well as rising average income of individuals are fueling the market growth. However, factors such as complicated and costly surgical procedures are likely to hamper the growth of the market. Lack of proper health care infrastructure, as well as awareness regarding diseases associated with obesity in middle-income countries, are also a major challenge to the market growth.

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The bariatric surgery devices market is mainly driven by the growing technical advanced devices, increasing prevalence of obesity, rise in the number of regulatory approvals, and increasing penetration of key market players. Also, with the increasing healthcare awareness, increasing innovation in R&D of medical devices, and favorable reimbursement policies along with growing average income are some of the favorable factors impacting the global market positively. Moreover, excessive intake of calories along with growing rate of obesity due to changing lifestyle habits are predicted to propel the market during the review period.

On the flip side, lack of proper health care infrastructure, complicated and costly surgical procedures are likely to inhibit the market growth globally. Additionally, a lack of awareness regarding obesity in middle-income industries poses a threat to the growth of the market.

Market Players:

Medtronic, Ethicon, Intuitive Surgical, Apollo Endosurgery, ReShape Lifesciences,  Aspire Bariatrics, EnteroMedics, Inc., Mediflex Surgical Products, TransEnterix, Inc., Agency for Medical Innovation

Market Segmentation   

The global bariatric surgery devices market is segmented on the basis of devices, procedure types, and end-user. According to the product, the market is segmented into assisting devices, implantable devices, and others.  The assisting device type is further segmented into suturing devices, stapling devices, incision closure devices, trocars, and others. Implantable devices are segmented into gastric bands, gastric balloons, electrical stimulation devices, and gastric emptying devices.

Considering the procedure, the market is segmented into sleeve gastrectomy, gastric bypass, revision bariatric surgery, non-invasive bariatric surgery, adjustable gastric banding, mini-gastric bypass, biliopancreatic diversion with duodenal switch, and gastric bypass.

On account of end-user, the market is segmented into bariatric surgery clinics, ambulatory surgical centers, hospital pharmacies, and others.

Based on region the market is segmented into Americas, Europe, Asia Pacific, and the Middle East and Africa. The American region is segmented into North America and South America. Similarly, Europe is segmented into Western Europe and Eastern Europe.

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Regional Market Summary

Americas is the global leader in the bariatric surgery devices market owing to increasing prevalence of obesity issues and diseases associated with it.  Additionally, factors such as increasing government initiatives and funding for research, development in advanced medical treatment options, increasing fast good chain, abuse of alcohol and drugs, and rising demand for technologically advanced treatment are likely to enhance the growth of the bariatric surgery devices market in the American region. For instance, according to the reports published by the American Society for Metabolic and Bariatric surgery in July 2016, the total number of bariatric surgery that was done in the U.S. in 2011 was 158,000. Moreover, key players are coming up with innovative solutions to solve the problem of obesity. In February 2017, Allurion Technologies, filed a regulatory filing to raise funds for the development of a non-endoscopic gastric balloon. The best thing about this drug is that it is in the form of a capsule which when swallowed gets inflated in the stomach and after months get deflated. This device does not require anesthesia for its use and is anticipated to revolutionize the bariatric surgery devices market.

Europe is the second largest market and holds a healthy share in the global bariatric surgery devices market due to major driving factors such as availability of advanced treatment facilities, increasing healthcare expenditure along with the growing need for better healthcare infrastructure, and government initiatives of healthcare reform. For instance, according to 2017 statistics presented by the European Society of Cardiology, there were more than 6 million reported new cases of cardiovascular diseases in the European Union and more than 11 million in Europe as a whole. Additionally, Europe spent around 210 Euros in 2015 for the treatment of cardiovascular disorders. Morbid obesity is the primary cause of cardiovascular diseases, and the only treatment to it is bariatric surgery as it does not respond to dieting or exercises. This is expected to have a positive impact on the bariatric surgery devices market.

Asia Pacific is expected to be the fastest growing market owing to the faster adaptation of healthcare technology, increase in patient pool due to obesity-related diseases, government initiatives to increase the healthcare quality, favorable insurance, and reimbursement policies, and key players such as Boston Scientific Corporation and Medtronic setting up their regional headquarters and manufacturing plants in Singapore, China, Japan, Korea, and Australia leading to the growth of bariatric surgery devices. In 2014, New Zealand invested about USD 40 million for its initiative against obesity. Moreover, raising adoption of western culture has led to the increasingly sedentary lifestyle such as addiction to alcohol and smoking and consumption of fast foods which are the direct causes of obesity. Raising awareness about the diseases associated with obesity also contributes to the bariatric surgery devices market growth. However, on the other hand, factors such as lack of skilled healthcare professionals may slow down the market growth during the forecast period.

The Middle East and Africa is expected to show the least growth in the market due to some major factors such as lack of awareness and limited access and availability of treatment facilities. In the Middle East, the United Arab Emirates is the largest market owing to the development of the healthcare industry and rising availability of specialty care centers.

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Leukemia Therapeutics Market Segments, Opportunity, Growth and Forecast by End-use Industry 2018

Leukemia Therapeutics Market Scenario:

Leukemia is blood cancer which most commonly in adults and children. Acute lymphocytic leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia are the major types of the leukemia. Leukemia therapeutics are used in treating the leukemia.

The global leukemia therapeutics anticipated to have held a market value of USD 10.7 billion in the year 2017 and is expected to grow at a CAGR of 5.3% during the forecast period.

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Segmentation

The global leukemia therapeutics market has been segmented into type, applications, and region.

Based on type, leukemia therapeutics market is segmented into chemotherapy, biological therapy, targeted therapy, radiation therapy, and stem cell transplant. The chemotherapy segment is expected to account for the largest share segment of the market in 2017. Chemotherapy segment further sub segmented into alkylating agents, antimetabolites, antitumor antibiotics, and others.

Based on applications, leukemia therapeutics market is segmented into acute lymphocytic leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, and others. The acute lymphocytic leukemia segment is expected to account for the largest share segment of the market in 2017.

Regional Market Summary

Geographically, the Americas is anticipated to dominate the global leukemia therapeutics market owing to a well-established player, innovative therapies to drive the market for leukemia, increase prevalence of leukemia, and increasing older population.

Europe is expected to hold the second largest position in the global leukemia therapeutics market. The market growth in this region is attributed to increase prevalence of leukemia.

The leukemia therapeutics market in Asia-Pacific region consists of countries namely China, Japan, Republic of Korea, India, Australia and Rest of Asia-Pacific. The Asia-Pacific region is expected to be fastest growing region.

The Middle East & Africa has the least share of the leukemia therapeutics market.

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Plasma Fractionation Market to Observe Strong Development by 2018

plasma fractionation process protein products are fractionated from human plasma for the prevention, and treatment of life-threatening conditions such as congenital deficiencies, immunologic disorders, and others.

Increasing prevalence of immunodeficiency disorders and rising healthcare expenditure are also boosting the plasma fractionation market in the US region. According to the 2018 study published in the Allergy, Asthma & Clinical Immunology journal, the estimated overall prevalence of immunoglobulin A (IgA) deficiency in the US was approximately 1 in 300 to 1 in 500 persons.

Global plasma fractionation market is expected to grow significantly over the forecast period. It is anticipated that the market held a valuation of USD 18073 million in 2017 and is projected to grow at a CAGR of 6.5% over the forecast period.

Various other factors such as increasing geriatric population, technological advancements, emerging markets in APAC and RoW, rising plasma collection, and increasing prevalence of respiratory and autoimmune disorders are also expected to propel the growth of the market.

However, the emergence of recombinant alternatives, high cost of advanced products, and unfavourable reimbursement policies can hamper the market growth over the forecast period.

Segmentation

The global plasma fractionation market is segmented based on product, application, end user, and region.

The global market for plasma fractionation, by product is segmented into immunoglobulin, coagulation factor concentrates, albumin, protease inhibitors, and others. The immunoglobulin segment is further classified as intravenous immunoglobulin (IVIG), subcutaneous immunoglobulin (SCIG), and others. The coagulation factor concentrates segment is further classified as Factor VIII, Factor IX, Von Willebrand Factor, Prothrombin Complex Concentrate, Fibrinogen Concentrates, and Factor XIII.

Based on application, the market is segmented into immunology, neurology, hematology, critical care, pulmonology, rheumatology, hemato-oncology, and others.

Based on end user, the market is segmented into hospitals & clinics, clinical research laboratories, academic institutes, and others.

In the current scope of the study, the above-mentioned segments are covered into the four global regions, namely the Americas, Europe, Asia-Pacific and the Middle East & African region.

The plasma fractionation market in the Americas has further been segmented into North America and South America, with the North American market divided into the US and Canada.

The European plasma fractionation market has been segmented into Western Europe and Eastern Europe. Western Europe has been classified as Germany, France, the UK, Italy, Spain, and the rest of Western Europe.  The plasma fractionation market in Asia-Pacific has been segmented into Japan, China, India, South Korea, Australia, and the rest of Asia-Pacific. The plasma fractionation market in the Middle East & Africa has been segmented into the Middle East and Africa.

Regional Market Summary

The Americas dominated the global market for plasma fractionation owing to the presence of major market players and increasing prevalence of immunodeficiency disorders within the region. According to the 2018 study published in the Allergy, Asthma & Clinical Immunology journal, the estimated overall prevalence of immunoglobulin A (IgA) deficiency in the US was approximately 1 in 300 to 1 in 500 persons.

In 2017, it was estimated that Europe stood second in the global plasma fractionation market. This can be attributed to the increasing technological advancements, and rising R&D investments.

Asia Pacific was projected to be the fastest growing region in 2017. Increasing healthcare expenditure drives the regional markets of the Asia Pacific region. According to the Australian Institute of Health and Welfare, from 2015 to 2016, the total health expenditure was USD 181 billion. Out of this, USD 69 billion was spent on hospitals, which is a real increase of USD 2 billion from the previous year. During the same years, non-government sources spent USD 55.8 billion on health.

On the other hand, the Middle East and Africa held least share in the global plasma fractionation market due to inadequate economic development, especially within the African region.

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Liquid Biopsy Market to show steady growth, 2018

Market Scenario:

Biopsy involves extracting a sample of tissue and testing it for the presence of diseases especially cancer. Traditional tissue biopsy is a painful technique and also has a high rate of false results. Moreover the technique is costly, time consuming and not applicable for extracting samples such as those close to vital organs such as heart. Liquid biopsy overcomes these problems of tissue biopsy by using biomarkers present in samples such as blood, urine etc. and thus is a comparatively non-invasive technique. Liquid biopsy also provides greater information about the sample which is real time. The real time data can be used for monitoring and thereby determining the treatment for diseases such as cancer. The greater sensitivity of tissue biopsy coupled with the development of sophisticated detectors with extremely low detection rates have enabled the early detection of diseases which is the holy grail of cancer.

Other market drivers for the liquid biopsy market are rising rates of cancer, growing investment in research and development, collaborations between companies and public organizations, rise in geriatric population, rising expenditure on health etc. The factors which are inhibiting the growth of the market includes the prohibitive costs associated with liquid biopsy and the differential awareness and availability between developing and the developed world. However, not all cancer patients benefit from early detection as some cancer types such as brain cancer and prostate cancer may lie dormant for many years. Further liquid biopsy is not all non-invasive as can be seen in case of using spinal fluid as sample.

Also the technique is not applicable to all types of cancer as some cancers such as brain cancer and prostate cancer may lie dormant for many years, and thus are either undetectable or detected very late which robs liquid biopsy of its advantages. Further liquid biopsy is not all non-invasive as can be seen in case of using spinal fluid as sample.

Major Players

Guardant Health, Inc., Trovagene, Inc., RainDance Technologies, Inc., Agena Bioscience Inc. Inc., Admera Health, Biocept, Inc., Circulogene Theranostics, Inivata Ltd., SAGA Diagnostics AB, Exosome Diagnostics and others.

Segmentation:

Global Liquid Biopsy market has been segmented on the basis of biomarker type which comprises of circulating tumor cells (Ctcs), circulating tumor DNA (Ctdna), extracellular vesicles (Evs) and other biomarker. On the basis of application; market is segmented into cancer therapeutic application, reproductive health, and other therapeutic application. On the basis of sample; market is segmented into blood, urine and others. On the basis of end-users; market is segmented into hospitals and laboratories, academic and research centres and others.

Regional Analysis:

Depending on geographic region, Liquid biopsy market is segmented into four key regions: Americas, Europe, Asia Pacific, and Middle East & Africa. Globally developed countries led by North America is the largest market for Liquid biopsy. Europe is the second-largest market for liquid biopsy. The developing regions market such as Asia pacific region and Middle East & Africa however is rising much faster.

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Cardiac Tamponade Market size and Key Trends in terms of volume and value 2018

Market Scenario

Cardiac Tamponade, is the build-up of fluid in the sac around the heart (pericardium) resulting in pressure and difficulty in compression of the heart which results in reduced blood volume to be pumped by the heart. The symptoms of cardiac tamponade include shortness of breath, weakness, light-headedness, cough, fatigue, swelling of the abdomen and veins in the arms or legs, or other areas, pale, blue or grey-tinted skin, rapid heartbeat, anxiety or restlessness, fainting etc. The causes of cardiac tamponade are cancer, kidney failure, chest trauma, pericarditis, connective tissue diseases, hypothyroidism, aortic rupture, post-operative consequences of cardiac surgery, tuberculosis etc. Cardiac tamponade can be life-threatening if not treated. Risk factors which increases the chances of cardiac tamponade include heart surgery, heart attack, injury to the heart, end-stage lung cancer, radiation therapy to the chest, hypothyroidism, systemic lupus erythematosus etc.

Diagnosis for this disorder is mostly based on x-ray, computed tomography (CT), Magnetic Resonance Imaging (MRI), coronary angiography, etc. The diagnosis may be further supported by ultrasound of the heart. Magnetic resonance imaging (MRI) is the diagnostic test of choice. The surgery segment is led by pericardiocentesis which involves drainage of the fluid by use of a needle. Cardiac tamponade occurs in approximately 2 per 10,000 individuals annually in the US alone.

The global cardiac tamponade market is expected to reach US$ 5.5 billion by 2023, and the market is projected to grow at a CAGR of ~ 5.5 % during the forecast period 2017-2023.

The market drivers for cardiac tamponade market are, increasing cardiac cases such as heart attack, cancer, kidney failure, end-stage lung cancer, hypothyroidism, rising screening and penetration of healthcare, growing awareness about cardiac diseases and growing income and healthcare expenditure etc. The market restraints are cost of cardiac tamponade surgery, complications and risk of the surgery along with invasive nature of this treatment.

Key Players

Some of key players profiled in the report are Boston Scientific Corporation, Medtronic, Inc., St. Jude Medical Inc., Hitachi, Ltd., Koninklijke Philips N.V., Siemens Healthcare Private Limited, Toshiba Medical Systems Corporation, General Electric Company, and others.

Segments:
The global cardiac tamponade market has been segmented on the basis of diagnosis, treatment, and end users.

Based on diagnosis, the market has been segmented as x-ray, computed tomography (CT), magnetic resonance imaging (MRI), coronary angiography, electrocardiogram (EKG) and others.

Based on the end users, the market has been segmented as hospitals & clinics, academic and research and others.

Based on treatment, the market has been segmented as surgery and drugs. The surgery segment has been sub-segmented as pericardiocentesis, thoracotomy and others. The drugs segment has been sub-segmented as antibiotics, blood volume expanders and others.

Regional Analysis

Asia Pacific region is expected to grow rapidly and China and India are likely to lead this market due to fast growing healthcare sector during the forecast period.

The Americas account for a significant market share owing to extensive use of medications and high expenditure on the health care. Additionally, the fastest uptake of new drugs in the US drives the cardiac tamponade market. Also, concentration of major research companies in the developed countries of this region is adding fuel to the market growth. The large expenditure by the US on healthcare accounting to 16% of GDP also cruises the sale of cardiac tamponade treatment. The large number of specialized cardiac centres in the US also drives the market.

Gulf nations such as Saudi Arabia and the UAE are estimated to drive the Middle East & African market. The development of large hospitals such as the King Fahd hospital in Riyadh is driving the market. The African region is expected to witness a moderate growth owing to poor economic and political conditions and poor healthcare development.

Europe is the second largest market in the world due to high income and healthcare penetration. Europe is led by countries such as Germany and France. UK is expected to be the fastest growing market.

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