Sunday, 7 June 2020

Global Clear Aligners Market 2020 Industry Analysis, Share, Growth, Trends and Forecast 2025


Market Research Future (MRFR) collected data on several factors including implications of covid-19 impact on microbiome sequencing services market and demographic challenges, showed how it could move forward in the coming years.
Global Clear Aligners Market size is expected to register 20.80% CAGR and is anticipated to reach USD 7019.96 Million by 2025. 
Clear aligners are an alternative to traditional braces and are designed to help arrange teeth into their proper position. Similar to braces, clear aligners use a gradual force to control the tooth movement, but without metal wires or brackets. The aligners are made of a durable plastic material and are fabricated to fit each individual's mouth.
Global clear aligners market share is driven by the increase in youth and geriatric population, growing dental service organizations, increase in dental procedures, and the rising prevalence of dental diseases. However, factors such as complications of clear aligners and the gray market for dental distribution are expected to restrict market growth during the forecast period.
Impact of Covid-19 Global Clear Aligners Market
The COVID-19 epidemic has been straining healthcare workflow across the globe. The disease has forced various industries to temporary shut its doors including many healthcare subdomains. Clear aligners have been one of the major markets that has been negatively impacted by COVID-19. The production for clear aligners has been disrupted across the globe. COVID-19 has forced various dentists to slash their services and staff resulting in delay in large number of appointments which is leading to increasing complications. Also, various events with respect to dental and clear aligners have been suspended. These events were supposed to be conducted in accordance to increase awareness and improve revenue for clear aligners. The company exocad, recently acquired by Align Technology, announced that its Insights 2020 event would be delayed to September 2020. Furthermore, the third congress of the European Aligner Society, which was supposed to be held in Malta from 19 to 21 March 2020, has been shifted to November 2020. The aim of this event was to introduce advances in technologies and techniques in aligner orthodontics and also major opportunity for various large manufacturers to enter into strategic alliances.
The company Align Technology, one of the leading players, accounts for more than 70% of the market share across the globe is also facing challenges in generating revenue due to COVID-19. In March, the company’s stock fell down by 20%. The analysis shows that the major reason for this was the lockdown in China where the company generated 8% of its entire revenue. The outcome of this lockdown is expected a $30 million to $35 million hit on revenue for the first quarter alone.
We have observed the massive impact of novel coronavirus on people’s lives over the last five months. It has also impacted various industries across the globe, eventually affecting the global economy. Some industries have experienced negative growth, whereas some industries have experienced tremendous demand and have generated massive revenues in this period. Covid 19 Impact on Clear Aligners market is the one of the positive impact sector on global industry
Clear Aligners Market Dynamics
The increasing expenditure on healthcare has minimized human efforts and increased the quality of patient care services. Moreover, the development of advanced technology in the healthcare industry has improved and provided many facilities to patients as per their needs, driving the growth of the global clear aligners market. For instance, according to the Official Portal of the UAE Government, approximately AED 3.83 billion (USD 1.00 billion) was allocated to the healthcare sector in 2015 in the UAE. Following the same course, AED 4.2 billion (USD 1.099 billion) was allocated for the healthcare and protection society in 2017.
Moreover, the growing youth and geriatric population, increasing prevalence of dental diseases, and technological advancements in dentistry are also expected to provide favorable conditions to the growth of the market during the forecast period.
However, the limitations of clear aligners and grey market for dental distribution are creating hurdles in the growth of the global clear aligners market.
Segmentation
The global clear aligners market has been segmented into product type, age, distribution channel, and region. 
Based on product type, the global market has been segmented into hard, medium, and soft.
Based on age, the global market has been divided into teenager and adult. The teenager segment is likely to hold the maximum share in the global market with a value of 1427.98 million in 2018.
Based on distribution channel, the global market has been divided into direct sales and distributor.
Clear Aligners Market Key Players
The prominent players in the global clear aligners market are Align Technology, Inc., Dentsply Sirona, Institut Straumann AG, Clarus Company, Danaher Corporation, and 3M.
Some of the key strategies followed by the players operating in the global clear aligners market were innovation, product development, acquisition, and expansion.
Regional Analysis
Global clear aligners market, based on region, is segmented into– the Americas, Europe, Asia-Pacific, and the Middle East and Africa.
The Americas is expected to command the largest market share due to aesthetic dentistry and other vast specialized services present in countries of North America. Additionally, the rising health expenditure per person and increasing demand for advanced technologies are driving the growth of the clear aligners market in these countries. Additionally, the presence of a large number of noticeable players in this region is the major driving factor of the market in the Americas.
Europe accounts for the second-largest market, majorly due to the soaring demand for dental procedures. Additionally, the increasing incidences of oral problems, vast application of technologically advanced techniques, and the growing importance of treatment, planning, and diagnosis in implant dentistry in European countries are driving the clear aligners market in Europe.
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Asia-Pacific with lots of opportunities and continuously growing economies is expected to be the fastest-growing region. Furthermore, recent developments in healthcare and improving economies and disposable income per individual are fueling market growth.
The Middle East & Africa is expected to grow significantly during the forecast period due to the increasing cases of dental abnormalities and the demand for better teeth-related treatments in the region.


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Liquid Biopsy Market Overview with Detailed Analysis, Competitive landscape, Forecast to 2022

Market Insights:
Liquid biopsy overcomes these problems of tissue biopsy by using biomarkers present in samples such as blood, urine etc. and thus is a comparatively non-invasive technique. Liquid biopsy also provides greater information about the sample which is real time. The real time data can be used for monitoring and thereby determining the treatment for diseases such as cancer. The greater sensitivity of tissue biopsy coupled with the development of sophisticated detectors with extremely low detection rates have enabled the early detection of diseases which is the holy grail of cancer.
Biopsy involves extracting a sample of tissue and testing it for the presence of diseases especially cancer. Traditional tissue biopsy is a painful technique and also has a high rate of false results. Moreover the technique is costly, time consuming and not applicable for extracting samples such as those close to vital organs such as heart.
Segmentation:
Global Liquid Biopsy market has been segmented on the basis of biomarker type which comprises of circulating tumor cells (Ctcs), circulating tumor DNA (Ctdna), extracellular vesicles (Evs) and other biomarker. On the basis of application; market is segmented into cancer therapeutic application, reproductive health, and other therapeutic application. On the basis of sample; market is segmented into blood, urine and others. On the basis of end-users; market is segmented into hospitals and laboratories, academic and research centres and others.
Major Players
  • Guardant Health, Inc.,
  • Trovagene, Inc.,
  • RainDance Technologies, Inc.,
  • Agena Bioscience Inc. Inc.,
  • Admera Health,
  • Biocept, Inc.,
  • Circulogene Theranostics,
  • Inivata Ltd.,
  • SAGA Diagnostics AB,
  • Exosome Diagnostics and others.
Drivers
The market drivers for the liquid biopsy market are rising rates of cancer, growing investment in research and development, collaborations between companies and public organizations, rise in geriatric population, rising expenditure on health etc. The factors which are inhibiting the growth of the market includes the prohibitive costs associated with liquid biopsy and the differential awareness and availability between developing and the developed world. However, not all cancer patients benefit from early detection as some cancer types such as brain cancer and prostate cancer may lie dormant for many years. Further liquid biopsy is not all non-invasive as can be seen in case of using spinal fluid as sample.
Also the technique is not applicable to all types of cancer as some cancers such as brain cancer and prostate cancer may lie dormant for many years, and thus are either undetectable or detected very late which robs liquid biopsy of its advantages. Further liquid biopsy is not all non-invasive as can be seen in case of using spinal fluid as sample.
Regional Analysis:
Depending on geographic region, Liquid biopsy market is segmented into four key regions: Americas, Europe, Asia Pacific, and Middle East & Africa. Globally developed countries led by North America is the largest market for Liquid biopsy. Europe is the second-largest market for liquid biopsy. The developing regions market such as Asia pacific region and Middle East & Africa however is rising much faster.
Key findings
  • Circulating tumor cells (CTCs) segment dominates both in terms of market share as well as revenues, contributing approx. 55.48% of the revenue share of the liquid biopsy market.
  • On the basis of the therapeutic application, the segment for Cancer will reflect the highest growth potential, with over 82.83% of the market share by revenues. However, the urine sample segment is anticipated to witness noticeable growth.
  • The market for liquid biopsy is dominated by North America and Europe and this trend will continue. Asia-Pacific market is the fastest growing market and is expected to grow at a CAGR of 29.7% during forecasted period
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Global Cranial Fixation and Stabilization Market 2020 – Investment Strategy, Outlook and Key Development till 2025

The Global Cranial Fixation and Stabilization devices Market is expected to reach USD 2.29 billion by 2025 at a steady CAGR of 8.90%.
Cranial fixation and stabilization is required during all surgeries and procedures involving the head. With new medical procedures increasingly relying on finesse and minimal invasion, the stability of the head is critical.
According to the WHO, over 6.8 million people die of neurological conditions each year. Consequently, the need for a deeper understanding of neurological conditions and the development of innovative surgical procedures are expected to drive the demand for cranial fixation and stabilization equipment.
The increasing use of biocompatible materials and synergetic technological growth along with medical advances are key to the development of the market, which is projected to expand in tandem with the progress of medical science and equipment.
Market USP
Critical need for the most advanced technologies and equipment when operating on the head and neck
Market Drivers
  • Increased global spending on healthcare
  • Large-scale technological advancements in healthcare equipment
  • Development of new and specialized surgical procedures to treat various neurological and head/neck trauma cases
  • Standardization of healthcare practices and procedures globally
  • Critical need for head/neck stabilization during surgery
  • Symbiotic growth of the healthcare and technology industries
  • Emphasis on reducing patient mortality

  • Increase in prevalence of neurological conditions such as epilepsy, stroke, neuroinfections, and traumatic injuries

  • Surge in the number of road accidents

Market Restraints
  • Stringent regulations regarding classification of cranial fixation and stabilization equipment as class II and class III medical devices
  • Different regulatory standards across the globe affecting imports and exports
Segmentation
By Category
  • Cranial Fixation Systems: Used for fastening bones after fractures, fastening skin to heal trauma, and for increasing cranial integrity post-surgery. Required for trauma cases, which make up the majority of brain surgeries, resulting in the segment accounting for the larger market share.
  • Cranial Stabilization Systems: Used to stabilize the head during invasive procedures. Required for intensive and delicate brain surgery procedures.
By Product
  • Meshes: Used for reconstructive procedures where part of the skull has been damaged.
  • Skull Clamps: Used to hold the head firmly in place for surgery.
  • Flap Tube Clamps: Used to attach cranial bones to the cranium in a singular motion.
  • Horseshoe Headrests: Used to stabilize the head by supporting the neck so head movement is still possible.
  • Plates: Used to replace skull parts that are too damaged to be repaired.
  • Screws: Used to attach fractured/broken cranial bones.
  • Accessories: Used to aid in the stabilization of the head by complementing other cranial stabilization systems.
By Type
  • Resorbable: These cranial fixation systems are eventually broken down and absorbed by the body. Resorbable equipment is more expensive but the segment accounts for a smaller market share.
  • Non-Resorbable: Cranial fixation systems that are either permanently attached to the patient’s cranium or require follow-up surgery for removal. Used extensively in developing countries due to their lower costs.
By End User
  • Hospitals: Cranial stabilization systems are almost entirely used by hospitals, while the majority of the cranial fixation systems also find application in this segment.
  • Ambulatory Surgical Centers: These establishments mostly deal with trauma cases and injuries that require immediate attention. However, these centers command disproportionate revenues due to the nature of their services.
  • Others: This segment covers on-site trauma and emergency surgeries.
By Region
  • Americas
  • Asia-Pacific
  • Europe
  • Middle East & Africa
Regional Analysis
  • Americas: With a massive 55% of the market share concentrated in North America alone, the market in the Americas is currently leading the global cranial fixation and stabilization market.
  • Asia-Pacific: This is the fastest-growing regional market due to the aggressive economic growth in the region, the increased spending on healthcare, and presence of a large patient pool of neurological disorders and head traumas requiring surgery.
  • Europe: Currently the second-largest, the European market is expected to register steady growth. Healthcare implementation in Europe occurs at the behest of the governments and not companies, making this a secure and stable market. However, the manufacture of medical equipment is privatized and, therefore, subject to stringent regulations. To fast track the regulatory process, the EU has created a single body for all member countries, thereby directly benefiting medium- and small-scale manufacturers.
  • Middle East & Africa: With limited medical infrastructure the regional market currently accounts for the least share of the global market. However, a young population, industrialization and urbanization, and increasing awareness of new medical procedures are expected to result in the eventual growth of the market.
Competitive Analysis
Key Players
  • Johnson & Johnson (US)
  • Stryker (US)
  • Ostomed (UK)
  • KLS Martin Group (Germany)
  • Medtronic (US)
  • Integra LifeSciences Corporation (US)
  • Braun Melsungen AG (Germany)
  • Changzhou Huida (China)
  • DePuy Synthes (US)
  • Evonos (Germany)
  • Jeil Medical (South Korea)
  • Medicon (Germany)
  • Micromar (Brazil)
  • NEOS Surgery (Spain)
  • Pro Med Instruments (Germany)
  • Zimmer Biomet (US)
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2020 Over-the-Wire Micro-Guide Catheter Market Growth Rate Research Report, Historical Analysis, Opportunities, Business Strategy and Potential of Industry 2023

Over-the-wire Micro Guide Catheter (OTW Micro Guide Catheter) is a thin tubular Medical device inserted into the body for diagnosis or treatments of diseases like cardiovascular, neurovascular, and urology. Specially designed to ease complex procedures, OTW Micro Guide Catheter combining excellent cross-ability and optimal guide-wire support, can effectively treat challenging cases involving tortuous vessels, CTO (chronic total occlusions), bifurcations, and highly stenosed and calcified lesions, giving the high success rate.
OTW Catheters are widely used in cardiovascular applications such as peripheral and coronary interventions and neurovascular interventional applications. The high success rate associated with the use of these catheters further augments its uptake and demand, resultantly driving its market growth.
According to Market Research Future (MRFR)’s global Over-the-wire Micro Guide Catheters market Size Forecast, the industry is expected to grow at a CAGR of 9.37% during the forecast period (2018–2023).
According to reports published by the Centers for Disease Control and Prevention, the coronary heart disease is the most common type of heart diseases that accounted for the death of about 366,000 people in 2015.
Over-the-wire catheters comparatively make a better choice to treat a brain aneurysm than the rapid exchange catheters owing to their capabilities of extra pushing to enter stenose vessels, and additional support that they provide.
The increasing occurrences of coronary heart diseases, neurovascular diseases, hypertension, and other metabolic disorders, raising awareness for health, advancement in technologies, good healthcare infrastructure, and favorable reimbursement policies are fueling the market growth. 
Regional Analysis
The global over-the-wire micro guide catheters market is segmented into four regions: the Americas, Europe, Asia Pacific, and the Middle East & Africa. Americas is the global market leader for over-the-wire Micro-guide catheters. As per the study published in the Surgical Neurology International in 2017, it was found that more than 3% population of the United States equivalent to nearly 10 million individuals have a brain aneurysm. North America commands for the major share of the market whereas; South America show the fastest growth of the market due to the presence of boundless growth opportunities.
Europe OTW Micro Guide Catheter market holds the second position, globally. This is primarily attributable to the increasing prevalence of obesity as well as the increased incidence rate of hypertension and diabetes, which in turn is escalating cardiovascular traumas and cardiac arrest. Each year 15% of deaths in Europe occur due to cardiovascular diseases claims a study conducted by European Society of Cardiology.
The Asia Pacific region is the fastest growing market for the over-the-wire micro guide catheters. The region presents significant growth opportunities for market players as local policy makers continue to restructure the policy framework for the healthcare sector.
Global OTW Micro Guide Catheter Market: Segmentation
The global over-the-wire micro guide catheters market is segmented on the basis of applications and end-users. On the basis of applications, it is segmented into cardiovascular and neurovascular. By the cardiovascular, it is segmented into angiography, angioplasty, peripheral stenting, and others. On the basis of the neurovascular, it is segmented into intracranial aneurysms, percutaneous neurointerventional procedures, and others. Based on end-user the market is segmented into hospitals & clinics, ambulatory surgical centers, research & academic institutes, and others.  
Major Players in the Over-the-wire Micro Guide Catheters Market
Enki – Microtubes, Cardinal Health, DePuy Synthes, Koninklijke Philips N.V, Penumbra Inc., Terumo Europe N.V., Integer Holdings Corporation, Merit Medical Systems Inc., Teleflex Incorporated, Cook Medical, Boston Scientific Corporation, Asahi Intecc Company Limited, and Medtronic plc.
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Friday, 5 June 2020

Herbal Medicine Market 2020: Size, Upcoming Trends, On-Going Demand, Growth and Forecast from 2020 to 2025 with Most Prominent Key Players

The Global Herbal Medicine Market value is expected to register a CAGR of 5.88% to reach USD 1,29,689.3 million by 2023.
Herb is a plant or plant part used for its scent, flavor, or therapeutic properties. Herbal medicines are a type of dietary supplements. They are sold as tablets, capsules, powders, teas, extracts, and fresh or dried plants. People use herbal medicines to maintain and improve their health. Many conventional drugs originate from plant sources, and most of the few effective drugs are plant-based. Examples include aspirin (from willow bark), digoxin (from foxglove), quinine (from cinchona bark), and morphine (from the opium poppy). The development of drugs from plants continues, with drug companies engaged in the large-scale pharmacologic screening of herbs.
Key Players
The prominent players in the global herbal medicine market are Arkopharma, Bayer AG, BEOVITA, Hishimo Pharmaceuticals, Schaper & Brümmer, ZeinPharma Germany GmbH, Venus Pharma GmbH, Dasherb Corp, and Arizona Natural Products among other.
Some of the key strategies followed by the players operating in the herbal medicine market trends were innovation, product development, acquisition, and expansion.
Market Dynamics
Herbal medicines are used since ancient times for numerous health conditions. It is the oldest and most extensively used system of medicine in the world today. There are various kinds of herbal medicines and supplements used across the world. According to the National Center for Biotechnology Information, 2015, the World Health Organization (WTO), reported that around 70% to 80% of people globally rely on herbal sources for their treatment. Also, according to the American Botanical Council, September 2017, it was reported that in 2016, the sale of herbal supplements increased by 7.7% in the US. It was also estimated that consumers spending on herbal supplements increased to USD 7.452 billion in 2016. Thus, the increase in the demand for herbal products for healthcare purposes is likely to enhance this market during the forecast period.

Segmentation
The global herbal medicine Market, by category, is segmented into herbal pharmaceuticals, herbal dietary supplements, herbal functional foods, and herbal beauty products. The herbal pharmaceutical segment led the herbal medicine market with USD 50,972.4 million in 2017. The herbal pharmaceutical segment is growing owing to the increasing research and development on various herbs to find their medicinal properties, growing demand for natural medicines having fewer side-effects, and rising prevalence of chronic diseases such as diabetes, arthritis, cancer, sleep disorders, and digestive problems.
Marrubium vulgare segment is the fastest-growing segment of the market at CAGR of 6.45% during the forecast period. Marrubium vulgare also known as white horehound is a largely cultivated plant, and its above-ground parts are used for medicinal use. The upper part of the plant is used in powder, liquid extract, or juice form for medicinal purposes. Marrubium vulgare is largely used for digestion problems which include indigestion, loss of appetite, gas, bloating, diarrhea, constipation, and gallbladder complaints. It is also used for the treatment of breathing problems
The global herbal medicine Market, by form, is segmented into extracts, powders, capsules and tablets, syrups, and others. The extracts segment accounted for the largest market share of 36.95% in 2017.
The global herbal medicine Market, by source, is segmented into leaves, fruit, roots, and barks whole plant, and others (combinations of various plant parts). On the basis of source, the leaves segment is expected to lead the global herbal medicine market. The leaves segment held a share of USD 51,495.2 million in 2017.
The global herbal medicine Market, by distribution channel, is segmented into hospital and retail pharmacies, e-commerce, and others. The hospital & retail pharmacies segment accounted for the largest market share of 55.82% in 2017. The growing prevalence of cancer and infectious diseases across the globe, improving healthcare infrastructure, and skilled professionals are driving the growth of hospital and retail pharmacies in the herbal medicine market.
Regional Analysis
Europe is expected to account for the largest market share owing to extensive R&D for herbal medicine, increasing funding for research on medicinal plants, and growing preference for herbal drugs globally. On a regional basis, Europe is segmented into Western Europe and Eastern Europe. Western Europe is estimated to lead market growth during the forecast period. The increasing prevalence of chronic diseases and rising government support facilitate market growth within the region.
Americas accounts for the second largest share in the global herbal medicine market. It accounted for a considerable market share of 16.2% as of 2017. The use of herbal medicines is also growing in the US after conducting the first national study of alternative and complementary medicines used by Eisenberg et al. According to the National Center for Biotechnology Information 2017, it was reported that herbal supplements were majorly used for conditions such as cancer (43.1%), stroke (48.7%), and arthritis (43%) in the US. Such a high demand and preference for herbal products is likely to boost the market growth during the forecast period.
Asia-Pacific is expected to register a CAGR of 5.99% during the forecast period owing to the adoption of traditional medicines by pharmaceutical companies, researchers, and policymakers. On the other hand, the Middle East and Africa are expected to observe a slow growth due to less awareness and in-depth knowledge about herbal drugs in this region.
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Invisible Orthodontics Market Growth Analysis, Industry Trends, and Forecast by 2025

Invisible Orthodontics Market share reached a value of USD 2598.8 Million in 2018 and is expected to register a CAGR of 13.99% during the assessment period of 2019 to 2025.
Global Invisible Orthodontics Market Analysis By Product Type (Clear Aligners, Braces, Clear Retainers), Age Group (Below 15, 16-35, Above 35), Application (Excessive Spacing, Crowding, Malocclusion, Others), Region (Americas, Europe, Asia-Pacific, Middle East & Africa) - Forecast to 2025
Market Synopsis
With the evolving technological advancements in the dental field, the area of invisible orthodontics has gained extensive popularity. Bracket-less aligners, clear retainers, and invisible braces some of the examples of cutting-edge technologies which have been launched in recent years. The high incidence rate of dental diseases in the developing countries and the rising inclination towards the correction of teeth deformities are likely to fuel the growth of the invisible orthodontics market across the globe. For instance, in Brazil, approximately 1.4 million new orthodontic cases are reported every year. Therefore, the key players involved in the invisible orthodontics market are vigorously focusing on product approvals to expand their customer base and brace their position in the market.
Moreover, the field of dentistry is evolving day by day. Public, as well as private organizations, are focusing on catering to the changing needs of the customers in terms of providing demos, conducting campaigns and dental check-ups. Thus, the employment of such strategies will promise the growth of the invisible orthodontics substantially.
Market Influencer
Increasing support by regulatory authorities to the private and public companies, in terms of investment and product approvals, acts as a significant factor that contributes substantially to the growth of the invisible orthodontics market in the longer run.
Market Drivers
  • The increasing prevalence of dental diseases pushes the need for newer treatment options, indirectly fueling the growth of the invisible orthodontics market globally. For instance, 90% of Australians are experiencing tooth decay. Such a high occurrence rate pushes the patients to choose newer techniques and prevention methods, thus fueling the growth of the invisible orthodontics market.
  • Several established players, such as Align Technology, Inc., and Dentsply Sirona are actively involved in getting approvals from regulatory authorities for their products in the invisible orthodontics market. For instance, in March 2017, Align Technology, Inc. launched the Invisalign Teen with mandibular advancement, the first clear aligner solution for Class II correction in growing tween and teen patients. This elucidates the impression that such new approvals are sure to drive the growth of the invisible orthodontics market in the near future.
  • Partnerships and collaborations between key players and local players
  • Increasing technological improvements in the orthodontics industry
  • High investment in research and development for the development of efficient products
  • Growing awareness created by dental professionals and key players about the benefits of clear aligners among the patients
Market Restraints
  • Limitations of invisible orthodontic products. Products such as clear aligners require long treatment time, which is why some of the patients do not prefer these products. In addition, poor compliance of patients with the dentists’ instructions leads to other complications of using these aligners. This results in a decreased target audience which would be utilizing such products, indirectly curbing the growth of the market.
  • Grey market for dental distribution, in terms of illegal selling of products of low quality at a cheaper price
Segmentation
By Product Type
  • Clear Aligners: The clear aligners segment is further segmented into hard, medium, and soft. The hard aligners sub-segment held a market value of an approximate of USD 1,394 million in 2018. The clear aligners segment held the largest share in 2018 due to a number of product launches by key companies such as Align Technology, Inc., Danaher, and others.
  • Braces: This segment has been further divided into ceramic braces and lingual braces. The braces segment is expected to be the fastest-growing during the forecast period owing to the increased awareness about the benefits created by key companies by conducting campaigns and dental check-ups.
  • Clear Retainers: A clear retainer is molded perfectly to fit the new position of the teeth.
By Age Group
  • Below 15: Various companies are getting approvals of their products for adolescents. In March 2017, Align Technology, Inc. launched the Invisalign Teen clear aligner for teenagers. Such increasing initiatives by prominent players for the below 15 age group fuels the growth of this segment.
  • 16-35: People in this age group are highly affected by dental disorders, including bite issues, due to change in lifestyle in recent years. This huge patient pool acts as a perfect target audience for prominent players to develop their products. Thus, the16-35 segment is likely to be the fastest-growing segment during the forecast period.
  • Above 35: The increasing middle-aged and geriatric pool of population suffering from dental caries, weakening of gums, abnormal eruptions in the teeth, among others, are the key factors for the growth of the above 35 segment. The benefits of clear braces are becoming palpable as a growing number of adult patients are now pursuing dental care.
By Application
  • Excessive Spacing: Spacing may prevent the teeth from functioning properly and may also result in gum problems due to the lack of protection provided by the teeth. Therefore, companies are coming up with products for corrective measures and conducting workshops and campaigns to create awareness. Thus, this segment held a majority share in 2018.
  • Crowding: Crowding can either be the result of several other orthodontic problems, such as impacted teeth, and teeth that do not fall out naturally, among others.
  • Malocclusion: The market, based on malocclusion, has been segmented into open bite, deep bite, and crossbite. The malocclusion segment is expected to be the fastest-growing segment during the assessment period owing to the increasing number of patients suffering from crossbites and open bites. Moreover, companies such as Align Technology, Inc. has a portfolio of products which are primarily used for the treatment of malocclusion. Thus, such factors are fueling the growth of this segment.
  • Abnormal Eruptions: Abnormal eruption occurs when a tooth emerges through the gum in the wrong place.
  • Others: Other applications of invisible orthodontic products are for correcting overjets, underbites, and others.
By Region
  • Americas: Americas was the largest regional market in 2018, owing to the continuous activities such as acquisitions, and partnerships employed by prominent players in the major countries in America. For instance, in March 2018, Dentsply Sirona (US) announced the acquisition of OraMetrix (US), a leading industry provider of innovative 3D technology solutions in the field of orthodontics. With this, the company aims to strengthen its position in the American invisible orthodontics market.
  • Europe: The European region holds the second largest share as there is increasing support from regulatory authorities, as well as ample of distributors in the European countries. For instance, in December 2017, Institut Straumann AG (Switzerland) acquired Same Day Solutions (SDS), a dental distribution company in Portugal. This acquisition provided Straumann access to SDS’ customers, which added the sales power and has been helping in supporting the company’s operations in Portugal.
  • Asia-Pacific: The Asia-Pacific region is anticipated to be the fastest-growing region in the global invisible orthodontics market. Direct marketing initiatives by the manufacturers to consumers are playing a substantial role in increasing the target audience and thus increasing the market size in this region. Also, strategic joint ventures by key players are contributing to the growth of the market. For instance, in January 2019, Institut Straumann AG, a company based in Switzerland, entered into a strategic partnership with a Chinese company, Tianjin ZhengLi Technology Company Limited. With this, Institut Straumann AG obtained exclusive distribution rights in China for its clear aligners, and the company aims to leverage its strong marketing and distribution capabilities to penetrate the highly attractive Chinese market. Thus, such strategies are likely to fuel the growth of the Asia-Pacific invisible orthodontics market.
  • Middle East & Africa: The smallest market due to limited healthcare infrastructure. But, in the last few years, top companies operating in the invisible orthodontics market are involved in acquiring different local distributors in the Arabian region to gain foothold in the local markets.
Key Players
  • 3M (US)
  • Align Technology, Inc. (US)
  • Clarus Company (US)
  • ClearPath Healthcare Services (US)
  • Danaher Corporation (US)
  • Dentsply Sirona (US)
  • DynaFlex (US)
  • Henry Schein, Inc. (US)
  • Institut Straumann AG (Switzerland)
  • Ormco (US)
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Global Biosimulation Market 2020 Business Insights & Deep Analysis to 2025 by World’s Top 10 Key Players

According to MRFR analysis, Biosimulation Market is expected to register a CAGR of 15.9% during the forecast period of 2019 to 2025 and is likely to be valued at USD 4.4 Billion by 2025.  
Biosimulation is a tool used for the prediction of the outcomes of existing clinical trials associated with innovation and new drug development.
The growth of the Global Biosimulation Market is determined by numerous factors such as the growing adoption of biosimulation software by regulatory bodies, increasing healthcare expenditure, increasing use of pharmacokinetic & pharmacodynamic modeling in pre-clinical development and rising need to reduce the drug development costs. However, lack of standardization in biosimulation methodology and lack of trained professionals for monitoring biosimulation software are likely to hamper the growth of the global biosimulation market during the forecast period.  
Several market players currently dominate the Global Biosimulation Market. The key players are involved in product launches and strategic collaborations to strengthen their market positions. For instance, in September 2019, Certara Inc. launched version 8.2 of Phoenix, the most advanced and widely used validated software for PK, PD, and toxicokinetic modeling and simulation worldwide.
Regional Analysis
The market has been divided, by region, into the Americas, Europe, Asia-Pacific, and the Middle East & Africa.
Americas has been segmented into North America and Latin America, with the North American market being divided into the US and Canada. The Americas is projected to hold the largest market share owing to the increasing R&D spending by pharmaceutical and biotechnology companies in the region and growing number of clinical trials & drug development practices.  
The European biosimulation market has been categorized as Western Europe and Eastern Europe. The Western European market has further been classified as Germany, France, the UK, Italy, Spain, and the rest of Western Europe. The biosimulation market in Asia-Pacific has been segmented into Japan, China, India, South Korea, Australia, and the rest of Asia-Pacific. Rising geriatric population and the presence of a large patient pool, are the key factors responsible for the fastest growth of the market in Asia-Pacific. The biosimulation market in the Middle East & Africa has been divided into the Middle East and Africa.
Segmentation
The Global Biosimulation Market has been segmented based on product, application, delivery model and end users.
The market, based on product, has been divided into software and services. The software segment is further segmented into PK/PD (pharmacokinetic/pharmacodynamic) modeling and simulation software, molecular modeling and simulation software, PBPK (physiologically based pharmacokinetic) modeling and simulation software, toxicity prediction software, trial design software, and others. The services segment is further segmented into in-house services and contract services. The software segment is likely to hold the maximum market share in the global biosimulation market owing to growing adoption of biosimulation software by pharmaceutical and research organizations and the increasing R&D investment for pharmaceutical research.
The global biosimulation market based on the application has been segregated into drug development, drug discovery, and others. The drug development segment is expected to hold a larger share of the market share owing to the rising adoption of biosimulation tool for the drug development process.
The delivery model segment of the market is divided into subscription models and ownership models.
Based on end users, the global biosimulation market has been segmented into pharmaceutical and biotechnology companies, contract research organizations, research institutes, regulatory authorities, and others. Rising adoption of inorganic growth strategies by different biosimulation service providers is likely to boost the adoption of biosimulation solutions in the pharmaceuticals and biotechnology companies.
Key Players
Some of the Key Players in the Global Biosimulation Market are Dassault Systèmes (France), Certara USA, Inc. (US), Simulation Plus (US), Schrödinger (US), Chemical Computing Group (Canada), Physiomics (UK), In Silico Biosciences (US), Advanced Chemistry Development, Inc. (Canada), Genedata AG (Switzerland), Nuventra Pharma (US), Evidera (US), Leadinvent Technologies (India), LeadScope, Inc. (US), Rosa (US) and INOSIM Software GmbH (Germany).
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