Thursday, 17 September 2020

Global Molecular Diagnostics Market 2020 To 2025 Professional Overview, Detail Analysis, Growth And Top Key Players Demand

 Market Highlights

The Global Molecular Diagnostics Market size is expected to register a CAGR of 8.57% during the forecast period, with a market value of USD 16,319.09 Million by 2025.

Molecular diagnostics is a collection of techniques used to analyze biological markers in genome and proteome. It helps to diagnose and monitor the diseases and decide which therapy should be administered to the patient based on the diagnosis. However, the rising prevalence of the infectious disease, increasing awareness regarding molecular diagnostic technique, and advancement in molecular diagnostics are the factors responsible for market growth during the forecast period.

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Rising prevalence of infectious diseases, advancements in molecular diagnostic techniques, and increasing prevalence of different types of cancer are likely to contribute to the growth of the market during the assessment period. For instance, as per a survey carried out by the World Health Organisation (WHO), around 9.6 million deaths caused by cancer were recorded in 2018 globally. However, stringent regulatory policies are likely to restrain the market growth during the forecast period.

Segment Analysis

The global molecular diagnostics market has been segmented into product, technique, application, and end user. By product, the market has been segregated into reagents & kits, instruments, and services & software. On the basis of technique, the market has been divided into polymerase chain reaction (PCR), isothermal amplification, hybridization, sequencing, microarray, and others. Based on application, the market has been bifurcated into infectious diseases, oncology, genetic tests, and others. By end user, the market has been categorized as hospitals & clinics, diagnostic laboratories, and others. The hospitals & clinics segment accounted for a market value of USD 4.078.09 million in 2018.

Market Players

Market Research Future (MRFR) recognizes the following companies as key players in the global Molecular Diagnostics market that include F. Hoffmann-La Roche Ltd (Switzerland), Hologic, Inc. (US), QIAGEN (Europe), Becton, Dickinson and Company (US), Abbott Laboratories (US), Cepheid (US), Siemens (Germany), CLONIT SRL (Italy), Thermo Fisher Scientific(US), Agilent Technologies(California), EKF Diagnostics (UK), Novartis (Switzerland), and Illumina (US).

Regional Analysis

The global molecular diagnostics market, based on region, has been classified as the Americas, Europe, Asia-Pacific, and the Middle East & Africa. The Americas is estimated to dominate the global molecular diagnostics market during the forecast period. This is attributed to the increasing geriatric population, and the availability of advanced healthcare facilities in the region play a vital role in the growth of the regional market. The Europe market for molecular diagnostics is expected to be the second-largest during the forecast period. The availability of funds for research & development and rising support from the government toward the life science sector is expected to boost the growth of the market in this region.

Additionally, the companies operating in the market are mainly focusing on mergers & acquisition, which is expected to support market growth. Asia-Pacific is estimated to be the fastest-growing market due to developing economies such as China, India, and South Korea emerging as major destinations for the outsourcing of clinical trials, drug manufacturing, and pathology testing. In addition to this, improving healthcare infrastructure has increased the number of research activities in the region. Moreover, in Asia-Pacific, China accounted for a market share of 21.4% in 2018. Furthermore, the market in the Middle East & Africa is expected to witness steady growth during the review period due to the lack of awareness regarding healthcare facilities.

Key Findings of the Study

  • The Global Molecular Diagnostics Market is projected to reach USD 16,319.09 million by 2025 at a CAGR of 8.57% during the review period from 2019 to 2025.
  • Americas accounted for the largest share of the global market due to the increasing geriatric population and the availability of advanced healthcare facilities in the region.
  • The hospitals & clinics segment accounted for a market value of USD 4.078.09 million in 2018

This research report provides insights, on various levels of analysis, such as industry analysis, market share analysis, leading market players, and their profiles. This report also helps in studying the target segments by providing views on emerging and high-growth segments and market conclusion. Together the market data comprises and discusses basic assessments on the competitive scenarios and strategies of the global molecular diagnostics market, including the high-growth regions and their political, economic, and technological environments. Furthermore, the project report also provides views over historical market values as well as pricing and cost analysis of the same.

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Global Type-1 Diabetes Treatment Market Recent Trends, Growth Opportunities, Forecast By Application And Types To 2025

 MARKET SYNOPSIS

The Global Type-1 Diabetes Treatment Market is projected to grow from USD 5.6 Billion in 2018 to USD 9.6 Billion by 2025, registering a CAGR of 7.9%.

Type-1 diabetes is a chronic condition that requires lifelong medication. The onset of this condition usually occurs in childhood; it also affects obese and aged individuals.

This condition has been directly linked to a sedentary lifestyle, the adoption of which is widespread globally due to various societal, cultural, and economic factors. The rising prevalence of type-1 diabetes is driving the growth of the market.

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Strict approvals processes are expected to hamper the growth of this market. However, this may be offset by the growing number of cases per year and increased government assistance for the management of the condition.

MARKET USP

The enhanced efficacy of rapid-acting insulin and rising number of specialty treatment centers for type-1 diabetes are aggressively driving the growth of the market.

SEGMENTATION

By Product

  • Rapid-Acting Insulin: The rapid-acting insulin segment is expected to be the largest and fastest-growing during the review period. Usually taken before the ingestion of food or drink, rapid-action insulin is easy to introduce into the bloodstream and starts acting within 15 minutes of injection. The segment has been further classified as Admelog, Humalog, Novolog, and others.
  • Short-Acting Insulin: Also known as regular insulin, it is included in the World Health Organization’s list of essential medicines.
  • Medium-Acting Insulin: This growth of this segment is directly proportional to the growth of the short-acting insulin segment as these insulin types are usually taken concurrently.
  • Long-Acting Insulin: This is a growing segment as this type of insulin does not have a peak performance time and is equally effective for the entire duration. It is preferred by healthcare agencies due to its low side effects and gradual action. The segment has been further categorized as Lantus, Levemir, and others.
  • Others: Ultra long-term insulin and other experimental insulins are covered in this niche market segment. Though currently the smallest segment, it shows tremendous growth potential due to the numerous beneficial effects and limited side effects of these types of insulin. However, the growth of the segment is limited by stringent regulations, a rigorous testing process, and high costs.

By End User

  • Hospitals & Clinics: This is the largest and fastest-growing market segment and is projected to grow well beyond the forecast period. Hospitals and clinics are the primary care centers for individuals afflicted with type-1 diabetes; they are also cost-effective. Moreover, in countries with government-funded healthcare and a high prevalence of type-1 diabetes, hospitals and clinics are the main treatment centers, which is driving the growth of the segment.
  • Specialty Centers: A more specialized treatment option, specialty centers have mushroomed across the US and are being opened in India and China. This segment is growing due to the increased number of individuals afflicted with the condition and the higher returns on investment from specialty centers as compared to hospitals and clinics.
  • Others: The ease of availability and delivery of diabetes medication has led to patients opting for home treatment. The segment also covers old age homes as the geriatric population is highly susceptible to type-1 diabetes. A niche segment, it is expected to grow as awareness regarding the condition increases along with ease of treatment.

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Wednesday, 16 September 2020

Global In-Vitro Diagnostics Market Drivers, Segmentations, Key Players, Analysis & Forecast 2020 - 2023

 Market Highlights

As per the latest report published by Market Research Future (MRFR) the global market for in-vitro diagnostics will record a CAGR of 8.16% between 2018 and 2023. The market is expected to surpass a valuation of USD 102,500 Mn by the end of the assessment period. In-vitro diagnostics (IVD) combines the application of reagents, medical devices and accessories for performing complex test procedures on biological specimens such as tissue, blood and urine taken from human body. In-vitro diagnostics is increasingly used for diagnosis of medical conditions and detection of infection. IVD has emerged as an important medical technology for overcoming challenges faced in diagnosis and management of diseases. Such factors are supporting the growth of the global IVD market.

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IVD is more precise than conventional test procedures and thereby gaining a quick popularity. In fact, many of the modern test procedures cannot be carried out without using IVD technology. Medical diagnostic device manufacturers are likely to capitalized on the market opportunity that has emerged. Demand for IVD services has grown substantially in recent years, which is attributable to the rising number of private diagnostics centers.   Moreover, advances in diagnostics technology coupled with the expanding global geriatric population, which is necessitating faster and more accurate diagnosis is likely to provide an impetus to the in-vitro diagnostics market in the forthcoming years. Other factors such as increased occurrence of chronic diseases and acceptance of molecular diagnostics in personalized medicines have also raised the importance of IVD.

Global In-Vitro Diagnostics Market: Segmental Analysis

MRFR’s report includes a through segmental analysis of the global in-vitro diagnostics market based on product & services, technology, application and end-user. Based on product & services, the market has been segmented into reagents & kits, instruments, and data management software. In 2017, the reagents and kits segment accounted for the largest market share. The segment is expected retain its top position over 2023, exhibiting a CAGR of 9.34%.  By technology, the market has been segmented into immunoassay/ immunochemistry, clinical chemistry, molecular diagnostics, microbiology and hematology. The clinical chemistry segment currently commands for more than one-third share of the market. This is primarily owing to the rapid integration of advanced technologies in clinical diagnostics. Meanwhile, the molecular diagnostics segment is projected to capture the highest during the assessment period. By application, the market has been segment into infectious diseases, and non-infectious diseases. In 2017, the infectious diseases segment accounted for over 60% of the market share. High prevalence of infectious disease is the primary driver of the segment’s growth. By end user, the market has been segmented into hospitals, laboratories and academic institutes. The hospitals segment holds the most dominant position – a majority of test are performed in hospitals. Hospitals continue to witness high patient influx despite the growing number of diagnostics centers.

Global In-Vitro Diagnostics Market: Regional Analysis

The in-vitro diagnostics market has been covered across North America, Europe, South America, the Middle East & Africa (MEA) and Asia Pacific (APAC). North America and South America collectively accounted for close to 40% share of the market in 2017. North America, in particular, is expected to remain highly lucrative market for in-vitro diagnostics. Easier accessibility along with high healthcare expenditure has a positive impact on the region’s market. The market in Asia-Pacific is likely to increase at a relatively higher CAGR over 2023.

Growth In-Vitro Diagnostics Market: Competitive Landscape

MRFR in its report has profiled some of prominent market players, which include Abbott Laboratories, Bio-Rad Laboratories Inc, Becton Dickinson and Company, Grifols S.A, Sysmex Corporation, Siemens AG, BioMérieux S.A, Ortho Clinical Diagnostics, Thermo Fisher Scientific, F. Hoffmann-La Roche AG, DiaSorin S.p.A, Danaher Corporation and Qiagen N.V

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Nano Therapy Market Covering Growth Inclinations & Development Strategies Until 2023

 Market Highlights

Nanotechnology has the potential to improve the drug solubility, stability, half-lives, and efficiency of the treatment. Nano therapy is a modern technique for treatment of various diseases and performed with the help of submicron sized molecular devices or nanoparticles. Nanotechnology offers the possibility to enhance drug dissolvability and strength, drag out medication half-lives in plasma, minimize off target impacts, and gather drugs at an objective site. This technology is characterized as submicron estimated atomic gadgets or nanoparticles prevalently running from 5 to 500 nm in one dimension. Generous past exploration exertion has brought about techniques to fuse helpful operators into biocompatible Nano devices including polymer nanoparticles, liposomes, micelle frameworks, inorganic nanoparticles, nanotubes, and dendrites.

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The market for Nano-therapy is blooming, as of now, around 250 Nano-medical products are being tested or used for humans. Nano therapy is majorly used in the treatment of diseases such as cancer, diabetes, cardiovascular disease and others. The major driving factors for the growth of the market are increasing the prevalence of cancer and other metabolic diseases. A recent study conducted by the Journal of Diabetes and Metabolic diseases has suggested the prevalence of MS ranged from 35.8 to 45.3 % in India and 30.5 to 31.5 % in China. Moreover, continuous development in technology, increasing demand for the better treatment, government support for research and development, and increasing healthcare expenditure of the people have fueled the growth of Nano therapy market. However, lack of regulatory standards in the examination of Nano therapy and higher cost of the treatment are the major factors that may restrict the growth of the market.

The global Nano therapy market is expected to grow at a CAGR of 8.2% during the forecast period 2017-2023.

Key Players for Global Nano Therapy Market

Some of the major players for the market are Smith and Nephew (UK), Selecta Biosciences, Inc. (US), Sirnaomics, Inc. (US), Tarveda Therapeutics (US), DIM (US), Cristal Therapeutics (the Netherland), CytImmune Science, Inc. (US), Luna (US), NanoBio Corporation (US), NanoBioMagnetics.n.nu (US), Nanobiotix (France), Nanoprobes, Inc. (US), Parvus Therapeutics (US), Nanospectra Biosciences, Inc (US), Nanosphere Inc. (US), NanoMedia Solutions Inc. (Japan).

Segmentation

The global Nano therapy market is segmented on the basis of technologies, applications and end users. On the basis of technology, the market is further segmented into nanomaterial and biological devices, Nano electronic biosensors, molecular nanotechnology, implantable cardioverter-defibrillators, and other. On the basis of applications, the market is segmented into cardiovascular disease, cancer therapy, diabetes treatment, rheumatoid arthritis, and others. On the basis of end users, the market is further divided into hospitals, clinics and research institutions.

 Regional Analysis

America dominates the global Nano therapy market owing to large diabetic population. According to National Diabetes Statistics Report, 2017, around 30.3 million people of all ages that is nearly 9.4% of the U.S. population had diabetes in 2015. Moreover, the accessibility of technology, increasing healthcare expenditure, and increasing government support for the research and development are some more factors supporting the growth in this region. Europe is the second largest nanotherapy markets, which is majorly driven by awareness and advancement in the nanotechnology sector. Asia Pacific is the fastest growing market owing to increasing demand for the better treatment options, and rising initiatives to include IT healthcare sector. Whereas, due to less development in technology, and low infrastructure level the market for Middle East & Africa will have limited growth in the nanotherapy market.

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Organ Transplantation Market - Global Industry Analysis, Size, Share, Growth, Trends, And Forecast 2020 - 2023

 Market Highlights

Organ transplantation is the replacement of the diseased or damaged organ with a health organ. Organs such as a kidney may be donated by living donors or harvested from brain-dead organ donors. Organ dysfunction caused due to severe injuries, cancer, organ failure and/or genetic disorders necessitate the requirement for organ transplant procedures. Advances in technology and development in the medical sector has made transplantation possible. Kidney, heart, lungs, liver and many more can be transplanted. An increasing number of organ transplantation surgeries across the globe are the major driving factor for the growth of the market. Technological development, increasing prevalence of chronic diseases, rising aging population and changing lifestyle has also contributed to the growth of the market. However, high cost of treatment and increasing incident of organ failure has hampered the growth of the market. Global organ transplantation market is expected to grow at a CAGR of 9.8% during forecasted period 2017-2023. 

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Segmentation:

Global organ transplantation market is segmented on the basis of type of organ, into heart, kidney, liver, lungs, and other. On the basis of products, they are segmented into organ preservation solutions, transplant diagnostics, tissue products and other. On the basis of type of transplant the market is segmented into autograft, allograft and allotransplantation, xenograft and xenotransplantation and other.

On the basis of treatment the market is segmented into analgesic, immunosuppressant and other. Immunosuppressant is further segmented into calcineurin inhibitors, mTOR inhibitor, antiproliferative agents, steroids and other. Calcineurin Inhibitors are sub segmented into tacrolimus and cyclosporine. mTOR inhibitor is sub segmented into sirolimus and everolimus.

On the basis of end users the market is sub segmented into hospitals, transplant centers and other 

Regional Analysis

On a regional basis, the global organ transplantation market is segmented into America, Europe, Asia Pacific and Middle East & Africa. America accounts for the largest market, owing to the huge number of people suffering from chronic diseases. An increasing number of organ transplantation, rising aging population and developments in the technology has also contributed for the growth of the market. Europe has the second largest market which is followed by Asia Pacific. Encouraging the start of new organizations and research, developed infrastructure and increasing healthcare expenditure has driven the Europe market. Asia Pacific has the growing market of organ transplantation. Rapid development in the healthcare sector, availability of skilled professionals and large diseases population pool is expected to fuel the growth of the market. Whereas, due to presence of poor economies in Africa and limited growth in healthcare sector is responsible for the lowest market of Middle East & Africa 

The major key player for the global organ transplantation market are Novartis International AG (Switzerland), Terumo Medical Corporation (US), Transonic (US), F. Hoffmann-La Roche Ltd. (Switzerland), Astellas Pharma, Inc (Japan), Preservation Solutions, Inc. (US),  OrganOX Limited (UK), Bio Med Pvt. Ltd. (US), Transplant Biomedical (UK), TransMedic, Inc. (US), Accord Healthcare GmbH (Spain), Sanofi (France), Pfizer, Inc. (US), Veloxis Pharmaceuticals A/S (Denmark), GlaxoSmithKline Plc. (UK) 

Global organ transplantation market is a competitive market. Major companies are investing in R&D so as to introduce more innovative and efficient methods and devices as they are under constant pressure to launch new and cost-effective method.

Novartis International AG is a Swiss multinational company headquartered in Switzerland and is one of the largest pharmaceutical companies. They are the leading manufacturer of analgesic drugs. In 2016, company has acquired Selexys Pharmaceuticals to increase its market. Company has launched, Zortress is the first in over a decade approved by FDA to prevent organ rejection in adult liver transplant patients.

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Sciatica Market 2020 Global Dynamics, Trends, Opportunities, Drivers, Challenges And Influence Factors Shared In A Latest Report

 Market Highlights

Sciatica is pain going down the leg from the lower back due to irritation of the lumbar or sacral nerves triggered by activities such as heavy lifting, jerky movements etc.Sciatica symptoms generally occur on one side of the body although in some cases it affects both sides. The symptoms include weakness or numbness in the affected leg, burning or tingling down the affected leg, and constant pain on one side of the rear. The causes of sciatica are spondylolisthesis, lumbar degenerative disc disease, osteophytes and arthritis of the spine, muscle spasm in the back or buttock, spinal stenosis, piriformis syndrome, pelvic tumours, pregnancy and others. However spinal disc herniation is the primary cause of sciatica in about 90% of the cases.

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Sciatica generally resolves on its own in about 90% of the cases. However severe sciatica may require surgical intervention if complications such as bowel or bladder problems occur. Sciatica affects 40% of people at some point in their life time and is most common during people's 40s and 50s, with men being more affected than women.

The market drivers for global market are rise in demand due to growing population, increasing screening, rising cases of geriatrics, rising safety and success of drug treatment, the extricating nature of the pain and others. The market restraints are the complications of surgery such as risk of bleeding, infections, pain, high cost of sciatica treatment, and others. 

The market drivers for global market are rise in demand due to growing population and greater number of procedures performed, increasing screening, greater consumption of starch rich diets and fast foods, greater emphasis on restorative dental procedures, rising efficacy, efficiency and success rate of treatment, and others. The market restraints are the complications such as risk of bleeding, infections, pain, high cost of treatment, loss of the tooth due to damaged and weak enamel, risk of developing abscess due to incomplete removal of infected material or if the antibiotics aren’t effective and others.

Product development represents the best strategy for the market growth. The market is expected to witness exponential growth over the review period owing to technological advancement in medical devices such as transcutaneous electrical nerve stimulation. Market development is another strategy for as there is a large unmet need in the developing regions such as India and China. Cost of the product will be a decisive factor in the developing regions such as Asia Pacific and especially Africa.

Global Sciatica Market Players

Some of the key players profiled in the report are Endo Pharmaceuticals, AstraZeneca, Novartis AG, Teva Pharmaceutical Industries, Neurotech, Nidd Valley Medical, Omega Laser Systems Ltd., Omron Healthcare, Inc., Sanofi and others.

Regional Analysis

The Americas accounts for a significant market share owing to high expenditure on the healthcare especially of the U.S. and Canada. Additionally, the greater number of orthopedic procedures due to greater healthcare penetration in the U.S. and Canada drives the market. The high concentration of the major hospitals in the developed countries of this region coupled with good reimbursement rates is adding fuel to the market growth. Moreover, the large share of surgical procedures especially the sciatica treatment in the returns of hospitals favors the market. The large number of medical devices companies in the U.S. is also a cause for the faster development of the market in the US.

Europe is the second largest market in the world due to growing medical devices industry and healthcare penetration. The European market growth is led by countries such as Germany and France. Germany is expected to be the fastest growing market over the assessment period due to its large medical devices industry.

Asia Pacific region is expected to grow rapidly; China and India are likely to lead this market due to fast growing healthcare sector and large unmet needs over the forecast period. The South East Asian countries such as China, India, and Malaysia are projected to contribute highly to the market growth. The growing penetration of healthcare industry in the Asia Pacific region is expected to drive the future market in the region.

Gulf nations such as Saudi Arabia and the UAE are estimated to drive the Middle East & African market. Other Middle East nations to watch out for are Kuwait, Jordan, Egypt and Iran. The African region is expected to witness a poor growth owing to poor economic and political conditions, and poor healthcare development. Other regions are expected to be laggards due to poor social development and tribal identities such as sub Saharan Africa.

Taste the market data and market information presented through more than 50 market data tables and figures spread over 80 pages of the project report. Avail the in-depth table of content (TOC) & market synopsis on “Global Sciatica Market” Research Report – Forecast till 2023.

Segmentation

The global sciatica market has been segmented on the basis of types, drug treatment, devices and end user.

Based on the types, the market has been segmented as L4 nerve root sciatica, L5 nerve root sciatica, S1 nerve root sciatica and others.

Based on the drugs, the market has been segmented as anesthetics, pain killers, muscle relaxants, antidepressants, steroids and others.

Based on the non-drug treatment, the market has been segmented as physiotherapy, acupuncture, stimulation devices, surgery and others.

Based on the end user, the market has been segmented as hospitals and clinics, research and academics and others.

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Global Integrated Cardiology Devices Market 2020 Insights Business Opportunities, Current Trends And Restraints Forecast 2023

 Market Overview

Global integrated cardiology device market is expecting enormous growth in coming future. Increasing prevalence of cardiovascular diseases, and growing adoption rates of minimally invasive surgeries and technological advances introduced in this field. Presently 30% of diseases occurring worldwide are cardiac diseases. There are various types of integrated cardiac devices such as Cardiology EMR Software, EHR (Electronic health record), FFR (fractional flow reserve), Optical Coherence Tomography and others which are advanced and most effective in treatment of cardiac diseases. High cost of the devices is mainly causing hindrance to the growth of this market.

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Expensive devices are the one of the major restraint for the growth of this market and so is the lack of infrastructure especially in the developing economies. 

Segmentation 

The global integrated cardiology devices market is segmented on the basis of types, applications and end users.

Based on types, the market is segmented as Cardiology EMR Software, EHR (Electronic health record), FFR (fractional flow reserve), Optical Coherence Tomography, others.

On the basis of application, they are segmented sudden cardiac arrest, internal monitoring, Cardiac resynchronization therapy, Cardiothoracic surgery, others. Cardiac Resynchronization Therapy (CRT) is an effective therapy in heart failure.

On the basis of end users, the market is segmented into catheterization laboratories, Hospitals and others. 

Regional Analysis
On regional basis, integrated cardiology devices market is segmented into America, Europe, Asia pacific, Middle East and Africa. For integrated cardiology the market is growing globally, where America accounts for the maximum share due to increasing prevalence of cardiac diseases. According to America’s Center disease control and prevention around 610,000 people die of cardiac diseases that’s 1 in every 4 deaths. Besides increasing expenditure in healthcare and well developed healthcare sector has also driven the growth of the market.

Europe commands for the second leading market which is followed by Asia pacific. Europe has always maintained a strong and well-developed infrastructure, due to increasing cardio-logical problems and eagerness to solve them by using integrated cardiology device market has driven this market in Europe. During the forecasted period, Asia Pacific is expecting fast growth. There are several factors leading to the growth for integrated cardiology devices such government initiation to improve public health and adoption of new therapies. Patients from well-developed nation come to Asian countries like India to get affordable treatments and this factor is forcing the growth of the market. Middle East & Africa showing slow but steady growth in the market due to inadequate development in medical sector and less health care expenditure. 

The major key players in global integrated cardiology devices market are Medtronic (US),  Boston Scientific Corporation (US), Medtronic (US), Jude Medical (US), Edwards Lifesciences Corporation (US), Abbott Laboratories (US), Johnson and Johnson (US), Getinge (Sweden), Terumo Corporation (Japan), Lepumedical (Bejing), Acrostak (Switzerland), Koninklijke Philips N.V. (Netherlands), Athenahealth, Inc. (U.S),others.

Key Players

Medtronic (US), Boston Scientific Corporation (US), Jude Medical (US), Edwards Lifesciences Corporation (US), Abbott Laboratories (US), Johnson and Johnson (US), Getinge (Sweden), Terumo Corporation (Japan), Lepumedical (Bejing), Acrostak (Switzerland), Koninklijke Philips N.V. (Netherlands), Athenahealth, Inc. (U.S),others.

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