Global Genotyping Market to Significant Growth Foreseen by 2023

 Market Highlights

Genotyping is a procedure commonly used in healthcare and life sciences research activities. Genotyping is a genetic mapping of an organism which includes DNA sequencing and analysis of sequenced DNA. The surge in cases of genetic disorders, increasing demand for personalized medicines, and technological advancement are the factors that are propelling the growth of the market. Additionally, increasing R&D spending and aggressive strategies adopted by the top players, such as new product launches, are contributing to the growth of the market. For instance, in January 2018, Illumina, Inc. launched iSeq 100 Sequencing System in the market, the product contains sequencing by synthesis (SBS) along with the complementary metal-oxide-semiconductor (CMOS) detection technology which is easy to use and compact product.  

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The unfavorable reimbursement policies, the dearth of technicians, and continues change in technology are likely to hinder market growth during the forecast period.

Regional Analysis

The market in the Americas is expected to dominate the global genotyping market size during the forecast period owing to the rising demand for personalized medicines, growing research and development sector, increasing cases of genetic disorders, and well-established healthcare sector in the region. The European market is expected to be the second-largest due to government funding and support of the healthcare sector, rising investment into research and development by pharmaceutical companies, and increasing government initiatives for development of healthcare sector. Moreover, the market in Asia-Pacific is anticipated to be the fastest-growing during the forecast period owing to the increasing disposable income, supportive government policies, and rising investment by market players in the region. The market in the Middle East & Africa is likely to account for the smallest share of the global genotyping market.

Segmentation

The Global Genotyping Market has been segmented on the basis of technology, product, application, and end-user.

The technology segment has been segregated into sequencing, capillary electrophoresis, PCR, microarray, and mass spectrometry. The sequencing segment has been further divided into next-generation sequencing, pyrosequencing, and Sanger sequencing. The Capillary electrophoresis segment has been further divided into amplified fragment length polymorphism (AFLP),single-strand conformation polymorphism (SSCP), and restriction fragment length polymorphism (RFLP). The microarray segment has been classified as DNA microarrays, antibody microarrays, MMChips, and peptide microarrays.

On the basis of product, the market has been divided into reagents and kits, instruments, and services.

 The market, by application, has been classified into diagnostics, drug discovery and development, agriculture, academic research, and personalized medicine.

The end-user segment has been classified into hospitals, diagnostic centers, academic institutes, and research and development centers.

Key Players

Some of the key players in the global genotyping market are F. Hoffmann-La Roche Ltd, QIAGEN, Thermo Fisher Scientific, Inc., Illumina, Inc, Fluidigm Corporation, General Electric Company, Affymetrix, Inc., Agilent Technologies, Inc., Sequenom, and Beckman Coulter, Inc.

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Global Ultrasound Probe Disinfection Market is Expected to Experience Immense Growth During 2020 – 2023

 Market Highlights 

The Ultrasound Probe Disinfection Market is expected to witness tremendous growth owing to the rising demand for disinfectant probes in hospitals, increasing cases of bacterial infection in healthcare center during the treatment, and increasing implementation of high-level disinfection process for critical ultrasound probes. The global ultrasound probe disinfection market was estimated USD 314.1 million in 2018 and expected to reach USD 819.1 million by 2023 at a healthy CAGR of 21.1% by 2023.

However, factors such as high cost of switching, maintenance cost for the ultrasonic instrument may hinder the market growth during the forecast period. 

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Segmentation

The Global Ultrasound Probe Disinfection Systems Market is segmented on the basis of product, probe type, by process and end-user. The ultrasound probe disinfection market, by product, is segmented into instrument, service, and consumables. The instrument is segmented into automated probe reprocessors, UV-C disinfectors, manual reprocessors/soaking stations, and ultrasound transducer storage cabinets. The consumables are sub-segmented into formulation, type of disinfectants, and detergents. The disinfectants, by formulation, is segmented into disinfectant wipes, disinfectant liquids, and disinfectant sprays. By type, consumables are segmented into high-level disinfectants, and intermediate/low-level disinfectants and detergents are segmented into enzymatic detergents and non-enzymatic detergents.

By probe type the market is segmented into linear transducers, convex transducers, phased array transducers, endocavitary transducers, transesophageal echocardiography transducers| (TEE), and other. On the basis of process, the market is segmented into high-level disinfection and intermediate/low-level disinfection. On the basis of end-user, the market is segmented into hospitals and clinics, diagnostic centers, ambulatory care centers, academic & research institutes, and others. 

Regional Analysis

The Americas leads in the market owing to the increasing prevalence of rising incidence of bacterial infection, increasing research & development in ultrasound probe disinfection and growing healthcare expenditure. According to the Consumer Report Organization and Centers for Disease Control and Prevention (CDC)  July 2015 publication, it is estimated that every year approximately 648,000 patients in the US got infected by bacteria during a hospital stay, and around 75,000 died. The increasing incidences of bacterial infection may support this market positively.

Europe is the second largest ultrasound probe disinfection market during the forecast period due to increasing prevalence of human papillomavirus (HPV). The human papillomavirus is a skin to skin transmitted disease. According to the Oxford Vaccine group fact sheet, HPV infection causes cervical cancers. It was also reported that 99% of cervical cancers are caused by the Human Papillomavirus (HPV) infection. Furthermore, it was also maintained that 3,126 new cases of cervical cancer were reported in the UK in 2015. The increasing prevalence of HPV infection supports the market growth in this region.

Asia-Pacific was estimated to be the fastest growing region for the global ultrasound probe disinfection market in 2017. The market is expected to witness high growth owing to the rising prevalence of bacterial infections. The Middle East and Africa holds the low share for this market. However, the rising healthcare awareness at the hospital and in the community are expected to influence the market positively.

Key Players

Some of the key players in the global ultrasound probe disinfection market are STERIS (UK), Nanosonics (Australia), Tristel (UK), Ecolab (US), Schülke & Mayr (Germany), Advanced Sterilization Products (US), CIVCO Medical Solutions (US), Germitec (France), Parker Laboratories (US), CS Medical (US), Virox Technologies (Canada), and Metrex Research (US).

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Liquid Handling System Market to Witness an Outstanding Growth by 2023

 Market Highlights

The global liquid handling system market is anticipated to hold a market value of USD 2.95 billion in the year 2017 and is expected to grow at a CAGR of 8.7% during the forecast period. Liquid handling system is generally used in the pharmaceutical, life science, or biochemical laboratories. The liquid handling system can perform simple, monotonous routine tasks as well as complex pipetting task efficiently.

 The growing investments in drug development, increasing demand for high-output screening, rising expenditure on research & development (R&D), and increasing adoption of automation in clinical settings are anticipated to propel the market growth during the assessment period. According to the data by The World Bank, the research and development expenditure (as % of Gross Domestic Product) was 1.70% in the United Kingdom in 2015. On the other hand, the high cost associated with the liquid handling systems and complex operability of the latest liquid handling systems may hamper the growth of the market over the forecast period.

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Currently, a large number of companies are engaged in developing liquid handling equpment market. For instance, Microlab VANTAGE, Microlab STAR, and Microlab NIMBUS are some liquid handling systems developed by Hamilton Company.

Regional Analysis

Geographically, the Americas is expected to dominate the global market owing to the presence of well-established healthcare sector, the high adoption rate of advanced technologies, and rising healthcare expenditures. Europe is anticipated to be the second largest market in the global liquid handling system market owing to the increasing R&D activities and continuously growing biopharmaceutical sector. Asia-Pacific region is anticipated to be the fastest growing region due to the improving scenario of life sciences-related research, increasing development in the healthcare sector, and rising government investments in the biotechnology and pharmaceutical sector. Furthermore, the Middle East & Africa has the lowest share of the global liquid handling system market.

Segmentation

The global liquid handling system market has been segmented into type, product, application, and end user.

The global liquid handling system market, on the basis of type, has been segmented into manual, automated, and electronic liquid handling system. The electronic liquid handling system segment held the largest market share in 2017 due to the high accuracy and reproducibility offered by the electronic liquid handling system.

The global liquid handling system market, on the basis of product, has been segmented into pipettes, consumables, microplate reagent dispensers, liquid handling workstations, burettes, software, and others. The pipette segment has been segmented into manual pipettes, electronic pipettes, and semi-automated pipettes. The consumables segment has been segmented into disposable tips, tubes and plates, reagent containers, and others.

The global market, on the basis of application, has been segmented into drug discovery, genomics, clinical diagnostics, proteomics, and others. The drug discovery segment has been segmented into ADME screening, high-throughput screening (HTS), compound weighing and dissolution, and others. The genomics segment has been segmented into genotyping, next-generation sequencing (NGS), polymerase chain reaction (PCR), DNA/RNA purification, and others. The clinical diagnostics segment has been segmented into sample preparation, ELISA, and others.

The global market, by end user, has been segmented into pharmaceutical & biotechnology companies, contract research organization (CRO), and others.

Key Players

Some of the prominent players in the global liquid handling system market are Agilent Technologies, Danaher Corporation, Thermo Fisher Scientific, Inc., Eppendorf AG, Tecan Group Ltd., Bio-Rad Laboratories, Sartorius AG, Mettler-Toledo International Inc., PerkinElmer, Inc., Corning Incorporated, and Hamilton Company.

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Electrical Hospital Beds Market is expected to rise at a remarkable CAGR By 2023

 Overview:

The global electrical hospital beds market analysis by MRFR prdeicts the market expected to touch a valuation of USD 2,595.4 million by 2023. The increasing medical tourism in developing economies has become a lucrative opportunity for major hospital chains. Electrical hospital beds are a necessity in hospitals which can assist patients with serious ailments in getting out of bed as well as provide a comfortable experience.

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Rise of chronic diseases, the expanding geriatric populace, increasing rates of obesity, and inflated healthcare expenditure of nations are factors which can positively impact the market growth. Improved designs by bed manufacturers which focus on comfort is likely to provide the electrical hospital beds market demand the thrust in the right direction. The high costs of these beds can act as a growth deterrent. But demand for smart hospital beds coupled with technological advances in the healthcare sector can facilitate global market growth.

Segmentation:

The electrical hospital beds market can be segmented by type, treatment, application, and end-user.

By type, the market is segmented into semi-automatic and fully automatic. The fully automatic segment accounted for 55% share in 2017, while the semi-automatic segment accounted for 45% share in the same year. The fully automatic segment is projected to experience a 8.83% CAGR over the forecast period owing to its extensive features such as controlling the lower part of the bed.

By treatment, the market covers acute care, critical care, and long term care. The critical care segment is expected to enjoy an 8.03% CAGR over the forecast period. It had dominated the market in 2017 owing to the sharp rise of electrical beds in intensive care units.

Major market applications include general purpose, intensive care, delivery/birthing, bariatric, pediatric, pressure relief, and psychiatric care. The general purpose segment accounted for the highest market share in 2017, followed by the intensive care segment. It is predicted to reign in the electrical hospital beds market over the assessment period owing to its high usage in sports academies, old age homes, rehabilitation centers, and others.

End-users in the electrical hospital beds market include hospitals and clinics, reproductive care centers, home care, and dentistry. Among these, the hospitals and clinics segment accounted for 40% market share in 2017, followed by reproductive care, dentistry, and home care segments. It is predicted to experience a 7.25% CAGR over the forecast period.

Regional Analysis:

The electrical hospital beds market covers the latest trends and opportunities across Americas, Europe, Asia Pacific (APAC), and the Middle East & Africa (MEA).

The European region accounted for 34% market share in 2017, followed by Americas (31%), APAC (25%), and MEA (10%). It can enjoy a 7.46% CAGR over the forecast period owing to its sophisticated healthcare infrastructure and emphasis on patient health by prominent nations. Countries such as the U.K., France, and Germany can drive the regional market size to USD 906.4 million by 2023.

The Americas region can enjoy a substantial growth rate over the forecast period owing to strong economies of Canada and the U.S. Introduction of beds with ergonomic designs and cost-effective prices are likely to induce massive demand from patients emphasizing on home care.

The APAC electrical hospital beds market is projected to grow at a rapid clip thanks to improvements in the healthcare sector, increasing medical tourism, and a dearth of opportunities owing to the large patient pool. It is expected to enjoy a 8.47% CAGR over the forecast period.

Competitive Dashboard:

Prominent players operating in the electrical hospital beds market include Paramount Bed Holding Co., Ltd. (Japan), Famed Zywiec Sp.zo.o. (Poland), Amico Group of Companies (Canada), Invacare Corporation (U.S.), Medline Industries, Inc. (U.S.), Merivaara Corporation (Finland), Span America Medical System, Inc. (U.S.), Linet spol.s.r.o. (Czech Republic), Gendron, Inc. (U.S.), ArjoHuntleigh (Sweden), Malvestio Spa (Italy), Stryker Corporation (U.S.), Midmark Corporation (U.S.), Hill Room Holding (U.S.), and Getinge AB (Sweden).

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Paraneoplastic Syndrome Market to Witness Widespread Expansion During 2020 to 2023

 Market Highlights

A paraneoplastic syndrome is a set of signs and symptoms which develops from tumor or cancer. This syndrome can be mostly seen in middle-aged to older patients and are often seen in patients suffering from breast cancer, lung cancer, and lymphatic or ovarian cancer. Sometimes, patients with paraneoplastic syndrome do not show symptoms even after the diagnosis, but there exists a rare condition where patients show symptoms of the paraneoplastic syndrome even before diagnostic tests are carried out.

Factors such as the increasing prevalence of cancer, awareness regarding breast cancer, and an unhealthy lifestyle drive the growth of the global paraneoplastic syndrome market. Moreover, rising investments in research and development activities and increasing healthcare expenditure are few more factors driving the global paraneoplastic syndrome market.

On the other hand lack of awareness regarding cancer and stringent regulations may hamper the growth of the market.

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The global paraneoplastic syndrome market is dominated by many market players. The key players in the market are engaged in new launches and strategic collaborations to hold their market position.  

Regional Analysis

The Americas is anticipated to dominate the global paraneoplastic syndrome market size. The market growth in this region is attributed to the increasing geriatric population with paraneoplastic syndrome disorder, investment in research and development, and technological advancements.   

Europe is expected to be the second largest market in the globe owing to the increasing number of geriatric population, increasing awareness regarding breast cancer, the presence of disposable income, and increasing consumption of tobacco in this region.  

Asia-Pacific is anticipated to be the fastest growing market owing to the growing prevalence of paraneoplastic syndrome and cancer-related problems in developing countries, increasing disposable income, and growing healthcare expenditure.

The Middle East and Africa is expected to account for the lowest market share in the global paraneoplastic syndrome market due to low development, lack of technical knowledge, and poor medical facilities in developing economies in this region.

Segmentation

The global paraneoplastic syndrome market has been segmented into types, diagnosis, treatment, and end users. Based on types, the market is segmented into the cutaneous paraneoplastic syndrome, gastro-intestinal paraneoplastic syndrome, endocrine paraneoplastic syndrome, hematologic paraneoplastic syndrome, renal paraneoplastic syndrome, rheumatologic paraneoplastic syndromes, and neurologic paraneoplastic syndrome.

The market, by treatment, has been segmented into medication and therapies. Medication is further sub-segmented into corticosteroids, immunosuppressants, anti-seizure medications, plasmapheresis, and intravenous immunoglobulin (IVIg). On the basis of therapies, the market is further sub-segmented into physical therapy and speech therapy.

The market on the basis of diagnosis has been segmented into blood test, spinal tap (lumbar puncture), and imaging tests. Imaging tests are further sub-segmented into computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and PET plus CT.

Based on end-user, the market is segmented into hospitals and clinics, diagnostic centers, and ambulatory care centers.

Key Players

Some of the key players in the global paraneoplastic syndrome market are Healthineers, Koninklijke Philips N.V., General Electric Company, Esaote SpA, NeuroLogica Corporation, Masimo Corporation, York Instruments Ltd., Neusoft Medical Systems, and Canon Medical Systems Corporation.

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Cerebrospinal Fluid Management Devices Market Poised to Witness a Significant Growth by 2027

 Cerebrospinal Fluid Management Devices Market Analysis

The Cerebrospinal Fluid Management (CSF) Devices market is growing pervasively. The market growth attributes to the rising prevalence of various neurological diseases and disorders. CSF devices are primarily used in the treatment of hydrocephalus, a condition that refers to the accumulation of cerebrospinal fluid (CSF) in the brain.  Hence, the growing awareness for this condition is also a significant factor that, along with the adoption of advanced and minimally invasive treatment procedures, escalates the market growth to furthered height.

According to Market Research Future (MRFR), the global cerebrospinal fluid management (CSF) devices market is estimated to grow at approx. 4.5% CAGR during the forecast period (2018 -2023). Also, factors such as the growing geriatric population and awareness about hydrocephalus propel the growth of the market. Simultaneously, the increasing prevalence of hydrocephalus in children boosts the market growth to an extent. Also, several risk factors leading to neurological disorders are creating enormous market demand.

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Additionally, increasing government funding and programs to support the R&D activities required for the development of CSF devices substantiate market growth. Furthermore, technological advances in the field of smart and connected devices, alongside the uses of some ubiquitous technologies such as Artificial Intelligence (AI) and the Internet of Things (IoT) to better diagnostic and treatment methods foster the market growth.

Conversely, factors such as the lack of trained professionals and side-effects associated with the treatment are projected to obstruct the market growth in years to come. Also, the high cost of CSF devices and lack of awareness for Hydrocephalus condition, act as major growth impeders for the market growth, especially in underdeveloped regions. Nevertheless, product launches of cost-competitive CSF devices would support the market growth throughout the anticipated period, filling the demand-supply gap.

Global CSF Devices Market- Segments

The report is segmented into four dynamics;

By Product: Shunts (Ventriculoperitoneal (VP), Ventriculoatrial (VA), Lumboperitoneal (LP), Ventriculopleural (VPL), others), Valve (Fixed and Adjustable), External Drainage Systems (External Ventricular Drainage (EVD) Systems, Lumbar Drainage (LD) Systems, others), and others.

By Age Group: Pediatric, Adult, and Geriatric.

By End User: Hospitals, Ambulatory Settings, Clinics, Research & Academic Institutes, and others.

By Regions:  Americas, Europe, Asia Pacific, and Rest-of-the-World.

Cerebrospinal Fluid Management Devices Market – Regional Analysis

North America dominates the global cerebrospinal fluid management devices market. The largest market share attributes to the strong presence of notable market players and a large base of patients suffering from various neurological diseases & disorders. Besides, the early uptake of technologically advanced medical devices for the treatment of the growing prevalence of neurological disorders in children and adults drive the regional market growth.

Furthermore, factors such as the increasing R&D support by the governments and high expenditures in neurological care substantiate the market growth. The North American CSF devices market is estimated to retain its dominance over the global market throughout the forecast period.

Europe stands second in the global cerebrospinal fluid management devices market. Growth is driven by rising research and development investments and increasing technological advancements. Moreover, factors such as the increasing incidents of neurological disorders and focus on the development of advent diagnostic devices contribute to the regional market growth. Also, rising government support for R&D activities, alongside the increasing numbers of specialty services offered by various healthcare providers in the region fosters market growth.

Asia Pacific is an emerging market for cerebrospinal fluid management devices. Factors such as increased healthcare expenditures and rising cases of hydrocephalus drive the growth of the regional market. Additionally, growing occurrences of neurological disorders in the region, fuel the market growth.  Furthermore, augmenting demand for quality devices to treat neurological diseases & disorders and penetration of healthcare technology provide impetus to the regional market growth, leading to increasing the uptake of CSF devices.

Global Cerebrospinal Fluid Management Devices Market- Competitive Analysis

Highly competitive, the CSF devices market appears fragmented, with a large number of players in the market churning the competition. Increasing incidences of drug resistance have opened doors for new entrants and leaders’ development of new devices and opportunities. The rise of spurious and counterfeit devices has reduced the total market revenues, displacing standard devices off the market.

Cerebrospinal Fluid Management Devices Market Major Players:

Players leading the CSF devices market include Integra LifeSciences Holdings Corporation, Medtronic plc, B. Braun Melsungen AG, Spiegelberg GmbH & Co. KG, DePuy Synthes, SOPHYSA, Dispomedica GmbH, Natus Medical Incorporated, Delta Surgical Limited, Moller Medical GmbH, Argi Grup, G. SURGIWEAR LTD., BeckerSmith Medical, Inc., and Wellong Instruments Co., Ltd., among others.

Cerebrospinal Fluid Management Devices Industry/Innovations/Related News:

May 15, 2020 —- Aesculap, Inc. (Germany), a leading medical device manufacturer, and its partner The Christoph Miethke GmbH & Co. KG (MIETHKE – Germany), launched the M.blue valve, the latest generation of Hydrocephalus valve technology in the US. The unique gravitational technology is integrated with a fixed differential pressure unit in one valve, allowing for a simple, position-dependent solution.

Aesculap, Inc. is a B. Braun company, the world’s largest manufacturers of surgical instruments, medical devices, and sterilization container systems. The MIETHKE develops, produces, and distributes innovative neurosurgical products for the treatment of hydrocephalus. The partnership demonstrates an impactful collaborative effort to bring better Hydrocephalus solutions to patients, such as the new M.blue valve.

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CBD (Cannabidiol) Market Estimated to Witness a Staggering Growth by 2026

 CBD (Cannabidiol) Market Overview 

Cannabidiol (CBD) is a natural compound present in the cannabis resinous flower, a plant with a long history as a medicinal drug stretching back several decades. Today scientists and physicians around the world are researching and verifying the medicinal effects of CBD. CBD is one of over a hundred “phytocannabinoids,” a healthy, non-addictive drug that is specific to cannabis and that endows the plant including its robust medicinal profile. CBD is closely linked to another essential phytocannabinoid involved in the medicine: tetrahydrocannabinol (THC), the compound that induces the high medical marijuana is known for. 

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CBD and THC both have great medicinal strengths. Unlike THC, however, CBD doesn’t really make someone feel intoxicated. This is because CBD and THC function on various brain receptors and bodies in differing ways. Indeed, CBD will mitigate or neutralize THC’s addictive properties, based on how much each compound is consumed. Most people like cannabis without the high-or with a little less a high-health benefit. The idea that CBD is both medicinally active and non-intoxic, and easier to take as a CBD oil, makes it an attractive treatment choice for those that try it for the first time. 

There’s plenty of hype about CBD’s healing abilities-for justifiable reason. But that wasn’t this until June 2018. Food and Drug Administration (FDA) has accepted cannabidiol as a true medication by recognizing Epidiolex, an almost pure form of prescription CBD, as a cure for two serious pediatric seizure disorders, Lennox-Gastaut syndrome and Dravet syndrome. It was the first time since the height of the reefer madness era 80 years ago – as “marihuana” was a felony rather than a treatment – that the administration gave an official thumbs-up for a drug extracted from cannabis. 

CBD Market Key Players

The prominent players in the global CBD market are Aphria Inc., Folium Biosciences, Freedom Leaf, Inc, Green Roads of Florida, LLC, CBD Health Solutions, LLC, ENDOCA, Isodiol International Inc, CV Sciences, Inc, Medical Marijuana, Inc., Canopy Growth Corporation, Elixinol Global Limited.

CBD (Cannabidiol) Market Segmentation 

CBD is not a wonder but a substance. Most people may greatly benefit from legal access to a wide variety of cannabis treatments, not just low-THC or no-THC products. CBD alone can not do the trick at all. There is ample evidence that CBD performs best when combined with THC and the wide range of other ingredients of cannabis. In order to understand the global CBD market in a better way, experts have segmented the market. 

Based on form, the market has been segmented into: 

• Solid
• Liquid 

By product: 

• Food Grade
• Therapeutic Grade 

By routes of administration: 

• Tincture
• Capsules
• Inhalation (Smoke or Vapor)
• Aerosol Spray 

By application: 

• Fibromyalgia
• Neurogenerative Disorder
• Diabetes
• Energy Drinks
• Protein Bars

By end user: 

• Food & Beverage
• Healthcare 

By source: 

• Organic
• Inorganic 

CBD (Cannabidiol) Market Regional Overview 

These are of course exciting times for the CBD industry. Experts believe that CBD’s future looks bright, with big international retailers willing to store a wider variety of CBD items. That being said, sounding a cautionary note is essential. Big, scientific studies are still in dearth, and several questions need to be answered. To better understand the global market for CBD at regional levels, industry experts have segmented the market based on regions which include North America, Asia Pacific, Europe, and the rest of the world. The countries covered in the report are India, China, the United States, the United Kingdom, Australia, Japan, Germany, and others. 

CBD (Cannabidiol) Industry News 

Newly implemented government plans for tribal hemp development are giving a strategic advantage to US sovereign countries in cultivating the plant and selling CBD, the communities claim. Following 80 years of ban, when U.S. farmers race to grow hemp, tribal territorial authorities realize they have such an edge so they can avoid red tape to become the first merchants on state markets to sell very own CBD.

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