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Tuesday, 4 May 2021

Q fever Market : The report gives immense knowledge on the competitive nature of key players 2027

The Global Q fever market size is expected to grow at CAGR of 7.83% to reach USD 6,249.68 thousand till 2023. Some of the protuberant drivers supporting the growth of the global Q fever market are identified as growth in the prevalence of chronic diseases and the increasing number of patients suffering from various bacterial infections.

The rising prevalence of Q fever coupled with increasing Q fever hospitalization rates, rising worldwide cattle, sheep, and goat population, growth in the risk factors of Q fever, and globally growing geriatric population are expected to drive the global Q fever market in coming years.

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Segmentation

Global Q fever, by type, segmented into acute and chronic. Chronic is the leading segment, which is growing at the highest CAGR to reach USD 706.20 thousand by the end of 2023. Chronic Q fever is a life threating problem and causes damage to the heart, lungs, liver, brain, and could cause diabetes as well. The major share of the chronic segment is attributed to its high prevalence.

Based on diagnosis, Q fever market is segmented into serology tests and others. The serology tests account for major share with 8.32% CAGR during the forecast period. Under the serology test, Q fever is diagnosed through antibody blood tests, polymerase chain reaction (PCR) tests, immunoperoxidase staining, complement fixation, enzyme-linked immunosorbent assay (ELISA) tests, and other molecular tests.

The Q fever market, by treatment, is segmented into antibiotic and surgery. The antibiotics segment accounts for the second largest share in the market with 7.32% CAGR during the forecast period. Surgery is an important component of treatment if patients have extensive valvular damage or indications of heart failure.

On the basis of end user, the market is segmented into patients, hospitals and clinics, and others. The patient segment accounted for a considerable market share of 72.1% as of 2017.

Regional Analysis

The Asia-Pacific accounted for the largest market share of 44.5% as of 2017 and is projected to grow at the highest CAGR of 8.57% during the forecast period. The increasing prevalence of chronic diseases such as diabetes, cancer, and bacterial infection in developing countries is the major driver for market growth. According to the International Diabetic Federation, about 415 million people had diabetes across the globe in 2015, which is expected to reach 642 million by 2040. It also stated that 98.4 million and 65.1 million diabetic population lived in China and India, respectively.

The Asia-Pacific is followed by Europe, which accounted for a major market share. The European market is expected to grow at a strong growth rate during the forecast period owing to the availability of advanced treatment facilities and healthcare expenditure along with growing pet adoption.

The Americas accounted for a significant share in the global Q fever market. It is attributed to the increasing adoption of pets, increasing preventive treatments, and care facilities for companion animals, rising technically advanced devices, and growing awareness regarding animal-transmitted diseases.

Key Players

The prominent players in the global Q fever market are Merck KGaA (Germany), Teva Pharmaceutical (Israel), Pfizer Inc. (US), Basilea Pharmaceutica Ltd (Switzerland), Sanofi S.A.(France), Melinta Therapeutics, Inc. (US), Bayer AG (Germany), Johnson & Johnson Services, Inc. (US), Yashica Pharmaceuticals (India), AtoxBio (US), and others.

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Transdermal (Percutaneous) Drug Delivery Systems Market Dynamics, Segments and Supply Demand 2020-2027

Transdermal Drug Delivery Systems Market Scenario

The global transdermal (percutaneous) drug delivery systems market growth is expected to register a healthy CAGR over the forecast period. The market held a market value of USD 5,400.2 million in 2017 and is projected to grow at a CAGR of 4.6% during the forecast period from 2018 to 2023. Transdermal drug delivery system (TDDS) delivers drugs through the skin to systemic circulation at a predetermined rate and maintain the effective concentrations clinically over an extended period. TDDS also called as patches are dosage forms that deliver a therapeutically effective amount of drug via the patients’ skin. Worldwide growing geriatric population along with rising in the prevalence of chronic diseases is the leading factor driving the market growth. In addition, rapid technological advancements in transdermal drug delivery systems and increasing adoption of third-generation delivery systems are expected to augment the market growth during the forecast period. The geriatric population is more prone to develop Q fever. The elderly population across the world is on the surge. The World Health Organization (WHO) reported that the worldwide population aged 60 years and above was 962.0 million in 2017, which is projected to increase to over 2.0 billion by 2050 and further would reach to 3.1 billion by 2100.

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However, disadvantages of delivery systems including edema and irritation, natural limits of drug entry imposed by the skin’s impermeability, and lack of adhesion of the transdermal system to different skin types are anticipated to hinder the market growth over the forecast period. Additionally, drugs that require high blood levels cannot be administered through TDDS as it is limited only to potent molecules, those requiring a daily dose of 10 mg or less, thereby affecting the market growth.

Transdermal Drug Delivery Systems Market Segmentation

The global transdermal (percutaneous) drug delivery systems market has been segmented into product, technology, application, and region.

By product, the market has been segmented into transdermal patches and transdermal semisolids. The transdermal patches segment is further categorized into drug-in-adhesive patches, matrix patches, reservoir membrane patches, and microneedle patches. The transdermal semisolids segment is additionally divided into gels, ointments, and sprays. The transdermal patches segment spearheaded the market in 2017 due to its benefits offered such as improved bioavailability, reduced dosing frequency, lower adverse events, enhanced patient compliance (non-invasive nature), painless application, and drug input termination at any point by the removal of the patch.

On the basis of technology, the market has been divided into electric current, iontophoresis, electroporation, ultrasound, microporation, thermal, and others.

Based on application, the market has been categorized into pain management, cardiovascular diseases, hormone replacement therapy, central nervous system disorders, smoking cessation, contraception, and others.

The global transdermal (percutaneous) drug delivery systems market has been segmented by region into the Americas, Europe, Asia-Pacific, and the Middle East & Africa. The transdermal (percutaneous) drug delivery systems market in the Americas has further been segmented into North America and Latin America, with the North American market divided into the US and Canada.

The European transdermal (percutaneous) drug delivery systems market has been segmented into Western Europe and Eastern Europe. The Western Europe transdermal (percutaneous) drug delivery systems market has further been classified as Germany, France, the UK, Italy, Spain, and the rest of Western Europe.

The transdermal (percutaneous) drug delivery systems market in Asia-Pacific has been segmented into Japan, China, India, South Korea, Australia, and the rest of Asia-Pacific. The transdermal (percutaneous) drug delivery systems market in the Middle East & Africa has been segmented into the Middle East and Africa.

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Global Hemostasis and Tissue Sealing Agents Market Show Steady Growth: Study 2027

Hemostasis and Tissue Sealing Agents Market Scenario

Global upcoming hemostasis and tissue sealing agents market trends is expected to grow significantly and is projected to grow at a CAGR of 8.6% over the forecast period. Hemostats, adhesives and sealants are useful aides to modern surgical procedures. Topical hemostats are utilized intraoperatively first and postoperatively to a reduce extent. These products can be utilized to diffuse raw surface bleeding, bone bleeding, oozing venous type bleeds, and needle-opening bleeding. There has been increasing demand for such products as it reduces complication during surgical procedures. Moreover, large number of surgical procedures across the globe are impacting the growth of the market positively. Surgical procedures are medical interventions involving an incision with instruments usually performed in an operating theatre and normally involving various medical devices such as catheters and tubes. For instance, according to the Center for Diseases Control and Prevention, approximately 46.5 million surgical procedures are performed every year in the U.S. Additionally, according to the NHS, surgery is the most important treatment offered by the NHS in secondary care within the UK. Furthermore, in 2015, NHS estimated that there were around 4.7 million surgical admissions in England, out of which 1.3 million procedures were for general surgery and around 1.2 million procedures were for trauma and orthopedics.

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These high surgical procedure numbers lead to rising need for hemostasis and tissue sealing agents which reduces the risk during surgical procedures. However, factors such as increasing advancement minimally invasive procedures, lack of reimbursement for these products is hampering the growth of the market.

Hemostasis and Tissue Sealing Agents Market Segmentation

The global hemostasis and tissue sealing agents market has been segmented into product, and end user.

By product, the market has been segmented into topical hemostats, and adhesive & tissue sealant. Furthermore, topical hemostats is divided into Active, mechanical (collagen based hemostats, cellulose based hemostats, gelatin based hemostats, polysaccharide based hemostats) Flowable. Adhesive & tissue sealant is further segmented into synthetic, natural, and adhesion barrier.

Further on the basis of end user the market is bifurcated into hospitals, ambulatory centers and others

The global Hemostasis and tissue sealing agents market has been segmented, by region, into the Americas, Europe, Asia-Pacific, and the Middle East & Africa. The diagnostics imaging workstations market in the Americas has further been segmented into North America and Latin America, with the North American market divided into the US and Canada.

The European Hemostasis and tissue sealing agents market has been segmented into Western Europe and Eastern Europe. The Western Europe diagnostics imaging workstations market has further been classified as Germany, France, the UK, Italy, Spain, and the rest of Western Europe.

The diagnostics imaging workstations market in Asia-Pacific has been segmented into Japan, China, India, South Korea, Australia, and the rest of Asia-Pacific. The diagnostics imaging services market in the Middle East & Africa has been segmented into the Middle East and Africa.

Hemostasis and Tissue Sealing Agents Market Key players

Johnson & Johnson, Cryolife, Inc., Baxter International, Inc, Ethicon LLC, Integra Lifesciences Corporation, Becton, Dickinson & Company, Cohera Medical, Inc., Pfizer, Inc, Medtronic plc, B. Braun Melsungen AG, MIL Laboratories Pvt. Ltd, Advanced Medical Solutions Group Plc

Hemostasis and Tissue Sealing Agents Regional Market Summary

Geographically, the Americas is anticipated to dominate the global hemostasis and tissue sealing agents market owing to the high clinical R&D budgets by both government as well as public and private organizations, presence of major manufacturers for the products, high number of surgical procedures and various others. Europe is expected to hold the second largest position in the global hemostasis and tissue sealing agents market. The Hemostasis and tissue sealing agents market in Asia-Pacific region consists of countries namely China, Japan, Republic of Korea, India, Australia and Rest of Asia-Pacific. The Asia-Pacific region is expected to be fastest growing region owing to increased medical tourism for surgical procedures, increasing healthcare expenditure in developing countries and various others. The Middle East & Africa has the lowest share of the global hemostasis and tissue sealing agents market. Majority of the market of the region is anticipated to be held by the Middle East region owing to the growing government initiatives for the healthcare sector.

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New research report offers detailed research on developments in Hyperpigmentation Disorders Treatment Market 2027

Market Scenario

The global upcoming hyperpigmentation disorders treatment market trends accounted for USD 3,915 million in 2017 and expected to register 7.1% CAGR during the forecast period (2018–2023).

Hyperpigmentation disorder refers to harmless skin condition that causes darkened skin patches light brown to black in color. It is a common disorder of the skin and melasma is a common cause of facial hyperpigmentation. There are various types of hyperpigmentation, however, few of the most common such as melasma, solar lentigines, and post-inflammatory hyperpigmentation.

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The increasing demands for outpatient and minimally invasive

dermabrasion procedures, include augmented adoption of lasers in pigmentation disorders treatment and growing expenditure on the cosmetics across the world are expected to drive the growth of the market. Moreover, rising R&D spending and aggressive strategies adopted by the top players such as new product launches are contributing to the growth of the market. According to the American Society of Plastic Surgeons, the number of dermabrasion cosmetic procedures have increased from 42,218 in 2000 to 88,182 in 2016 with a 109% increase during the estimated period.

The lack of adequate reimbursement policy and high costs involved in the establishment of these centers may hamper the growth of the market during the assessment period.

Key Players

Some of the key players in the global hyperpigmentation disorders treatment market Allergan, Inc., Bayer AG, EpiPharm AG, Episciences, Inc., Galderma laboratories (Nestle Skin Health S.A), Obagi Cosmeceuticals LLC, Pierre Fabre, RXi Pharmaceuticals Corporation, SkinCeuticals International, and Vivier Pharma.

Intended Audience

Medical devices manufacturers
Pharmaceutical Companies
Medical devices product distributors and suppliers
Healthcare providers
Research institutes and academic centers
Government associations
Market research and consulting

Market Segmentation

The global hyperpigmentation disorders treatment market has been segmented on the basis of treatment type, disease indication, end-user, and region.

On the basis of treatment type, the market has been classified as topical drugs, chemical peels, microdermabrasion, laser therapy, phototherapy, and others. the market, by disease indication, has been segmented into melasma, solar lentigines, post-inflammatory hyperpigmentation, and others. based on end-user, the market has been segmented into hospitals, aesthetic clinics & dermatology centers, and others. The topical drugs segment is expected to hold the largest market share of the hyperpigmentation disorders treatment market, by treatment type, during the forecast period. Also, by disease indication melasma segment register the considerable growth in comparison to other disease indication.

The market has been segmented, by region, into the Americas, Europe, Asia-Pacific, and the Middle East & Africa. The hyperpigmentation disorders treatment market in the Americas has further been segmented into North America and South America, with the North American market divided into the US and Canada.

The European hyperpigmentation disorders treatment market has been segmented into Western Europe and Eastern Europe. Western Europe has further been classified as Germany, France, the UK, Italy, Spain, and the rest of Western Europe.

The hyperpigmentation disorders treatment market in Asia-Pacific has been segmented into Japan, China, India, South Korea, Australia, and the rest of Asia-Pacific. The hyperpigmentation disorders treatment market in the Middle East & Africa has been segmented into the Middle East and Africa.

Regional Market Summary

The Americas market is expected to be the second-largest hyperpigmentation disorders treatment market. The market growth in this region can be attributed to government funding and support of the healthcare sector coupled with increasing research and development. Moreover, favorable reimbursement policies in American countries are contributing to the growth of the market in this region.

Europe is expected to be the third largest hyperpigmentation disorders treatment market during the forecast period owing to the rising in aging population. Moreover, the government of these countries are more focus to provide best treatment option to their citizen. According to the report published by world health organization, Europe aging population will increase from 14 million in 2016 to 19 million in 2020 and 40 million to 2050.

The market in the Middle East & Africa is expected to account for the smallest share of the global hyperpigmentation disorders treatment market due to an underdeveloped healthcare sector, lack of technical knowledge, and poor medical facilities.

The Asia-Pacific are likely to dominate the global hyperpigmentation disorders treatment market owing to the rising awareness of hyperpigmentation disorders, presence of rapidly developing healthcare technology, huge patient population, and high healthcare expenditure. Moreover, Asia-Pacific is also expected to be the fastest-growing Hyperpigmentation Disorders Treatment market during the forecast period. According to the world bank group, in 2014, China spent 4.96% of gross domestic product (GDP) in healthcare expenditure, whereas in 2015, healthcare expenditure holds 5.32% of GDP. Also, in 2014, India spent 3.63% of GDP on healthcare, however, in 2015 healthcare expenditure holds 3.89% of GDP.

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Transarterial Chemoembolization (TACE) Market Current Trends, SWOT Analysis, Strategies, Industry Challenges, Business Overview and Forecast Research Study 2027

Market Forecast

Transarterial Chemoembolization (TACE) Market is expected to cross USD 2777.22 Million by 2025 at a CAGR of 8.57%.

The increasing prevalence of liver cancer is expected to drive the growth of the global transarterial chemoembolization (TACE) market. Hepatocellular carcinoma (HCC) is fifth cancer in terms of incidence and the second leading cause of cancer death for men worldwide. The incidence of HCC is highest in Asia and Africa.

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Improvement in the reimbursement scenario is impacting the growth of the market. The cost of sorafenib is reimbursed by Taiwan’s National Health Insurance (NHI) administration with the TACE procedure. Moreover, Lipiodol is approved for National Health Insurance reimbursement for transcatheter arterial chemoembolization for HCC.

Segmentation

By Procedure Type

Conventional TACE: Conventional TACE dominated the Transarterial chemoembolization (TACE) market as it is one of the oldest procedures used in HCC cases. Conventional TACE involves the infusion of chemotherapeutic drugs blended with lipiodol and embolic agents into the cancer-feeding artery

DEB-TACE: This segment is expected to witness the fastest growth. DEB-TACE allows higher concentrations of drugs to the target tumor and lower systemic concentrations, compared with conventional TACE

By Indication

Unresectable HCC: TACE is a major treatment modality for unresectable HCC. The liver tumor which is not eligible for resection therapy given the extent of disease is considered as unresectable HCC

Early-Stage HCC: In case of early-stage HCC, TACE is recommended if resection or local ablation is not feasible

By Product Type

Chemotherapeutic Agents: Held the largest market share in 2018. Doxorubicin, cisplatin, and mitomycin are most commonly used in the TACE procedure. Doxorubicin is the most widely used chemotherapeutic agent for TACE of HCC. The dose of doxorubicin generally ranges from 30 to 75 mg/m2

Radiotherapeutic Agents: TACE with radiotherapeutic agents is the most expensive treatment for liver tumors.

Drug-eluting Particles: Drug-eluting beads have been imposed as novel drug-delivering agents for TACE. DC Beads is one of the most commonly used Drug-eluting beads. These beads are nonbiodegradable PVA microspheres, loaded with calibrated doxorubicin

By End-User

Hospitals & Clinics: It holds the largest market share that can be attributed to an increase in the number of patients afflicted by HCC, coupled with a rise in a number of hospitals, and quality care, and availability of skilled and qualified professionals.

Cancer Research Centers: This is the fastest-growing segment due to increasing research funding for the development of effective treatment of HCC

By Region

Americas: The region holds the largest share of the market. The market in the Americas has further been branched into North America and Latin America, with the North American market divided into the US and Canada.

Europe: The European transarterial chemoembolization (TACE) market has been classified as Western Europe and Eastern Europe. The Western European market has further been categorized as Germany, France, the UK, Italy, Spain, and the rest of Western Europe.

Asia-Pacific: The market in Asia-Pacific has been segmented into Japan, China, India, South Korea, Australia, and the rest of Asia-Pacific. The Asia-Pacific transarterial chemoembolization (TACE) market is projected to be the fastest-growing during the forecast period.

Middle East & Africa: The market in the Middle East & Africa has been divided into the Middle East and Africa.

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Seborrheic Dermatitis Treatment Market – Functional Survey 2027

Seborrheic Dermatitis Treatment Market is expected to cross USD 3.28 Billion by 2025 at a CAGR of 10.5 %.

Market Synopsis

Seborrheic dermatitis is a chronic inflammatory disorder that mostly affects the head and face. Primarily environmental, genetic, and general health problems are the cause of this disorder. The exact cause of seborrheic dermatitis remains unknown, but factors such as a change in hormone is the primary cause of this disease. It frequently affects people post-puberty. The prevalence of seborrheic dermatitis has been rising significantly in recent years. In the US alone, approximately 300 people are diagnosed with seborrheic dermatitis annually making it a reasonably common dermatological disorder worldwide. Some factors influencing the market growth are the rising awareness of personal hygiene, advancement in treatment options for seborrheic dermatitis, and growing awareness regarding seborrheic dermatitis.

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The global seborrheic dermatitis treatment market is currently dominated by several market players. The key players are involved in product launches and strategic collaborations to strengthen their market positions.

Regional Analysis

The market has been divided, by region, into the Americas, Europe, Asia-Pacific, and the Middle East & Africa. The Americas is expected to be the largest market owing to the increasing prevalence of seborrheic dermatitis and rising per capita healthcare expenditure. The seborrheic dermatitis treatment market in the Americas has further been branched into North America and Latin America, with the North American market divided into the US and Canada. The European seborrheic dermatitis treatment market has been categorized as Western Europe and Eastern Europe. The Western European market has further been classified as Germany, France, the UK, Italy, Spain, and the rest of Western Europe. The seborrheic dermatitis treatment market in Asia-Pacific has been segmented into Japan, China, India, South Korea, Australia, and the rest of Asia-Pacific. Due to the increasing patient pool of skin disorder and raising awareness about seborrheic dermatitis, the market in Asia-Pacific is expected to be the fastest-growing. The seborrheic dermatitis treatment market in the Middle East & Africa has been divided into the Middle East and Africa.

Segmentation

The global seborrheic dermatitis treatment market has been segmented based on treatment type, route of administration, and end user.

The market, based on treatment type, has been divided into antifungal products, corticosteroid lotions, and sulfur products. Around 1.5 million Americans are diagnosed with various seborrheic dermatitis every year. The corticosteroid lotions segment is predicted to be the fastest-growing due to the rising prevalence of the disorder in the pediatric population.

The global seborrheic dermatitis treatment market has been segmented, on the basis of route of administration, oral, and topical. The oral segment is expected to hold the majority share of the market. Around 25 million adults are diagnosed with chronic seborrheic dermatitis every year, and most of them treated with the help of oral drugs. The topical segment is expected to be the fastest-growing due to its increasing use globally. It was estimated that around 1.3 million people in the US were afflicted with seborrheic dermatitis in 2018.

The end-user segments of the market are hospital pharmacies, retail pharmacies, and others. The hospital pharmacies segment is expected to hold the largest share of the market as these centers are the primary locations for patients receiving treatment and services.

Key Players

Some of the key players in the Global Seborrheic Dermatitis Treatment Market are Sonoma Pharmaceuticals (US), Merck (US), Hikma Pharmaceuticals (UK), Allen and Hanburys (UK), GlaxoSmithKline (UK), Bausch Health (Canada), Valent Pharmaceutical (UK), and West-Ward Pharmaceutical Corp. (US).

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Healthcare Cyber Security Market Is Seeing Explosive Growth by Future Industry Winners: Forecast, 2020-2027

Healthcare Cyber Security Market is expected to register a CAGR of 11.82% to reach USD 16,393.15 Million till 2025.

Cyber security is a method of protecting systems, networks, and programs from digital attacks with the help of specific software. Healthcare cyber security is the adoption of cyber security solutions and services by healthcare organizations to protect the patient and hospital information from data breaches and cyberattacks. Healthcare cybersecurity is a growing concern due to the exponential rise in healthcare data breaches in recent years. According to the Health Insurance Portability and Accountability Act (HIPAA) Journal, more than 113 million records were breached in 2015. The growing data breaches in the healthcare sector is propelling market growth.

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The key factors responsible for driving the market growth are an increase in cyberattacks and data breaching, regulatory and government norms, and increasing use of Internet of things (IoT) devices in the healthcare industry. However, the limited awareness of cyber security in the healthcare industry and lack of adoption of updated software are projected to curb the growth of the market.

Market Dynamics

Cyberattacks and data breaching are growing in the healthcare industry, with the increase in technological advancements. Healthcare organizations such as hospitals & clinics, pharmaceutical companies are highly targeted and affected by cyberattacks and data breaching. Healthcare records are valuable sources for attackers as they contain highly sensitive data, which include social security numbers, bank information, and other personal health information. These medical records can be used for healthcare insurance fraud as a means of getting and selling prescription medications in the black market.

In the medical device industry, medical device hacking and ransomware virus attacks have caused significant losses to healthcare providers. Machines used in hospitals such as X-rays, life-support devices, and pacemakers have malware planted in them. These malware programs can then transfer throughout the network to infect other devices and applications, including the entire system. According to the US Department of Health and Human Services Office for Civil Rights, the cases of data breaches in healthcare had increased by 63% in 2016. According to a whitepaper published by the Department of Health & Human Service, healthcare breach cost in the US has increased significantly in recent years.

Segmentation

The global healthcare cyber security market is segmented into threat type, solution type, and end user. Based on threat type, the market has been segmented into malware, distributed denial-of-service (DDOS), advanced persistent threat (APT), and others. Based on the solution type, the global healthcare cyber security market has been categorized as antivirus and antimalware, risk and compliance management, security information and event management (SIEM), DDOS mitigation, identity and access management, and others.

Regional Analysis

The Global Healthcare Cyber Security Market, based on region, has been divided into the Americas, Europe, Asia-Pacific, and the Middle East & Africa.

The Americas are expected to hold the largest share of the global healthcare cyber security market. The growth of the Americas can be attributed owing to the increasing cases of data breaches, and the availability of advanced healthcare information technology (IT) solutions are expected to drive the market growth in this region. According to the HIPAA Journal, the number of reported healthcare data breaches has been steadily increasing each year. In 2018, 365 healthcare data breaches were reported, up almost 2% from the 358 data breaches reported in 2017 and 83% more breaches that 2010.

Europe is expected to account for the second-largest market share during the forecast period. The European market for healthcare cyber security has been further segregated into Western Europe and Eastern Europe. Western Europe has been segmented into Germany, the UK, Italy, Spain, France, and the rest of Western Europe. The factors responsible for market growth in this region are the presence of highly developed medical & healthcare infrastructure, and high spending on healthcare IT drives the market growth in this region.

Asia-Pacific is estimated to be the fastest-growing market owing to the rapid development in technology, and the presence of enormous opportunities for the development of the market drives the growth of the Asia-Pacific healthcare cyber security market.

The Middle East & Africa is expected to grow at a steady rate in the healthcare cyber security market due to factors such as increasing capita income, and rising healthcare infrastructure support accounted for a relatively smaller market share in 2018.

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