Obstructive Lung Disease Market Growth, Trends and Value Chain 2020-2027

 Obstructive lung disease is a category of respiratory disease characterized by airway obstruction. Many obstructive diseases of the lung manifest due to the narrowing of bronchi which often cause excessive contraction of smooth muscles. The major types of obstructive lung disease include asthma, bronchiectasis, bronchitis and chronic obstructive pulmonary disease (COPD). Increase in prevalence of COPD and asthma patients, rising geriatric population, increase in pipeline products, growing government and non-government initiatives for spreading awareness are the major factors driving the growth of the global obstructive lung diseases market.

As per the Global Burden of Disease study, it is estimated that chronic obstructive pulmonary disease caused 3.2 million deaths globally in 2015. Disease burden due to COPD was the highest in India, Nepal, Papua New Guinea, and Lesotho. COPD manifests itself as an occupational hazard in people working in agriculture, mining, plastics, and other industries.

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Governments across each country have implemented regulations for the production, standardization, and utilization of COPD devices. These devices are divided into categories –Class-I, Class-II, Class-III, and Class-IV, depending upon the level of risk associated.

However, stringent government regulatory requirement for the approval of asthma and COPD drugs, side effects associated with the drug treatment, and patent expiry of drugs restrict the market growth.

The global market of obstructive lung disease is expected to grow at a CAGR of approximately 8.5% during the forecast period 2017-2023.

Intended Audience

• Obstructive Lung Disease Drug Suppliers
• Obstructive Lung Disease Drug Manufacturers
• Obstructive Lung Disease Device Suppliers
• Obstructive Lung Disease Device Manufacturers
• Research And Development (R&D) Companies
• Medical Research Laboratories
• Academic Medical Institutes and Universities

Segmentation

The obstructive lung disease is segmented on the basis of disease type, product type, drug class, route of administration and end-users.

On the basis of disease type, the market is segmented into asthma, bronchiectasis, bronchitis and chronic obstructive pulmonary disease (COPD), and others

On the basis of product type market is segmented into inhalers, and nebulizers and others. Inhalers are divided into Drug Powder Inhalers (DPIs), Metered Dose Inhalers (MDIs), Soft Mist Inhalers (SMIs) and others. Moreover the nebulizers are divided into compressor nebulizers, ultrasonic nebulizers, and mesh nebulizers

On the basis of drug class, the market is segmented into combination drugs, leukotriene antagonists (LTA), inhaled corticosteroids (ICS), anticholinergics, short acting beta agonists (SABA), long acting beta agonists (LABA), and others. Furthermore, the Combination products is divided into seretide/advair, symbicort, relvar/breo ellipta, flutiform, dulera, and others. Leukotriene Antagonists (LTA) is divided into singulair and others. Inhaled Corticosteroids (ICS) is divided into qvar, pulmicort, aerospan, flovent, and others. Anticholinergics is divided into Spiriva and Others. Short Acting Beta Agonists (SABA) is divided into proair, ventolin, and others.

On the basis of route of administration, market is segmented into oral, inhaler, intravenous, subcutaneous, and others

On the basis of end-user, the market is segmented into hospitals & diagnostic centers, academic institutes, pharmaceutical & biotechnology companies and others.

Key Players

The leading market players in the Asthma and COPD Drug focus to expand their business operations in the emerging countries. The companies operating in the market have consistently introduced innovative solutions to enhance their product portfolio. Product approval and clinical trial are observed as the two prominent growth strategies adopted by the key market players.

Some of key the players in the global obstructive lung disease market are GlaxoSmithKline (GSK) (U.K), Novartis AG (Switzerland), Merck & Co. Inc. (U.S), Abbott Laboratories (U.S), Boehringer Ingelheim (Germany), AstraZeneca (U.K), Roche Holding AG (Switzerland), Teva Pharmaceutical Industries (Israel), Vectura Group (U.K), Pfizer Inc. (U.S), Mylan (U.S.), Aerovance Inc. (U.S.), Alkermes Inc. (U.S.),  Almirall SA. (U.S.), Genentech Inc. (U.S.), Sepracor, Inc. (U.S.), Skyepharma plc (U.S.).

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Moyamoya Disease Market to Witness Widespread Expansion During 2020-2027

 Moyamoya disease (MMD) is a chronic, cerebrovascular disease characterized by progressive stenosis in the internal carotid artery and an abnormal vascular network at the base of the brain. The stroke is one of the significant symptoms of moyamoya disease, which further leads to paralysis of the face, arms, and legs, loss of speech, and temporary loss of neurologic function of body parts, visual disturbances, headaches, developmental delay, and seizures.

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According to the National Organization for Rare Diseases, in Japan, moyamoya disease is estimated to occur in 1 per 1 million people, and the condition is more prevalent in females under the age of 20. It is also reported that nearly 10% of cases of moyamoya disease in Asian countries have a genetic cause. Recently, two major mutations have been found to be associated with a specific population of moyamoya patients i.e. R179, and RNF213 mutations.

Intended Audience

• Pharmaceutical Companies
• Research and Development (R&D) Companies
• Diagnostic Laboratories
• Government Research Institute
• Academic Institutes and Universities

Key Players

Some of key the players in the global moyamoya disease market are Abbott Laboratories, Boston Scientific Corporation, Cephalon, Inc., Cordis Corporation, Eisai Co., Ltd, GE Healthcare, Genentech Inc., GlaxoSmithKline PLC., Johnson & Johnson, Koninklijke Philips N.V., Medtronic plc, Merck & Co. Inc., Novartis AG, Pfizer, Inc., Sanofi, Siemens, Stryker,, Sunovion Pharmaceuticals, Inc., UCB Pharma Ltd., Valeant Pharmaceuticals International, Inc. and others.

It is noted that growing public awareness and technological advancements are the key factors driving the moyamoya disease market. Nowadays, people are becoming more aware of different types of neurological disorders. Government and other different organizations have started educating people about hygiene and diseases through seminars, and conferences. People are becoming more aware and health conscious. Thus, increasing awareness has provided a push to the growth of the market. The new and existing marketers are also contributing to control this condition. For instance, on April 13, 2016, Silk Road Medical, Inc., received FDA approval for its next-generation ENROUTE Transcarotid Neuroprotection System (NPS). The NPS is specifically designed and indicated for transcarotid artery revascularization.

Various other factors such as increased incidence of neurological disorders, unmet medical needs, increasing government assistance, improving regulatory framework, increasing adoption rate, and rising funding and reimbursement are continuously contributing to the growth of the global moyamoya disease market.

Despite these drivers, there are some issues associated with moyamoya disease market. The challenges in research and development, cost of treatment, side-effects of treatment, the presence of misbranded and spurious drugs, and poor healthcare system in low and middle-income countries, may hinder the growth of the market to an extent.

It is estimated that the moyamoya disease market is expected to grow at a CAGR 7.0% during the forecast period of 2017-2023.

Segmentation

The global moyamoya disease market is segmented on the basis of diagnosis, treatment, and distribution channels.

On the basis of the diagnosis, the market is classified as a cerebral angiogram, magnetic resonance imaging (MRI), magnetic resonance angiogram (MRA), computed tomography (CT) scans, transcranial Doppler ultrasound, positron emission tomography (PET) scan, and electroencephalography (EEG).

On the basis of the treatment, the market is classified as surgical treatment and non-surgical treatment. The surgical treatment is further classified as pial synangiosis, indirect procedures, and direct arterial bypass. The sub-segment of indirect procedures includes EDAS (encephaloduroarteriosynangiosis), EMS (encephalomyosynangiosis), Omental transposition/transfer, and dural inversion. The non-surgical treatment is further classified as anticoagulation and antiplatelet therapy, and others. The sub-segment of anticoagulation and antiplatelet therapy include heparin, warfarin, aspirin, and others.

On the basis of the distribution channel, the market is segmented into hospitals, clinics, diagnostic centers, drug stores, pharmacies and others.

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Nonallergic Rhinitis Market to Witness Widespread Expansion During 2020-2027

  Also known as vasomotor rhinitis, nonallergic rhinitis is a medical condition that causes chronic sneezing, and congestion. Although the symptoms of nonallergic rhinitis are similar to that of allergic rhinitis, it does not involve the immune system. This condition can be diagnosed with, physical examination, allergy test such as skin test, blood test, and imaging tests such as CT scan. Treatment includes use of nasal sprays, oral decongestants, and over-the-counter (OTC) drugs or prescription medications.

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Rising prevalence of nonallergic rhinitis, and increasing demand for diagnosis and treatment of nonallergic rhinitis are the major factors driving the growth of the market across the globe. Furthermore, increasing healthcare expenditure and overall growth of healthcare industry also influences the market growth. Splendid research in the field of immunology also boost the market. Additionally, increasing focus on the development of new medications for the treatment of nonallergic rhinitis, and increasing use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) also fuel the market growth. The growth of the market is restricted by increasing competition among key players in the market that act as a barrier of new entrants.

The global nonallergic rhinitis market is expected to grow at a CAGR of 5.3% during the forecast period.

Segments

The global nonallergic rhinitis market is segmented on the basis of diagnosis, treatment, and end user.

On the basis of diagnosis, market is categorized into physical examination, allergy testing, imaging test, and other segments. Allergy testing is further segmented into skin test and blood test. Imaging test is further segmented into nasal endoscopy, and computerized tomography (CT) Scan.

On the basis of treatment, the market is segmented into nasal sprays, NSAIDs and others.

Nasal sprays is further segmented into saline, corticosteroid, antihistamine, decongestants, and anti-drip anticholinergic.

On the basis of end user, the market is segmented into hospitals & clinics, research centers, and others.

Regional Analysis of the Global Nonallergic Rhinitis Market               

America holds the first position in the market for nonallergic rhinitis owing to the rising prevalence of nonallergic rhinitis in the U.S., and consequent increase in the demand for new diagnostic and treatment services. In Americas, North America is the largest market owing to the presence of key players in the industry. As per the Warren Alpert Medical School of Brown University, the prevalence of nonallergic rhinitis has been observed to be one-third that of allergic rhinitis, affecting ~7% of the U.S. population or ~22 million people. Additionally, rising awareness about morbidity due to nonallergic rhinitis and the presence of key players in the market also influence the growth of the market.

Europe is the second largest market for nonallergic rhinitis. In Europe, there is an increasing demand for nasal sprays, and extensive research and development activities by clinical research and academic institutes for chronic diseases treatment. Germany, and France are the largest contributors to the market growth owing to an increase in the number of market players manufacturing NSAIDs, and overall growth of healthcare industry.

The market in Asia Pacific is expected to grow at the fastest pace and is driven by an increasing number of patients suffering from nonallergic rhinitis and increasing awareness about the diagnosis and treatment. India, China, and Japan are major contributors to the growth of the market. This growth is attributed to an increasing demand for nasal sprays and OTC medicines and availability of highly qualified medical personnel dedicated to the research of chronic diseases.

The Middle East & Africa also show a steady rise in the market owing to low prevalence of nonallergic rhinitis and increasing awareness about allergic and nonallergic rhinitis treatment. In the Middle East & Africa, the Middle East captures the largest market share for availability of specialty medical services and increasing expenditure on healthcare

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3D Cell Culture Market to Witness Widespread Expansion During 2020-2027

 3D cell culture is a technique in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. Besides, the ability of 3D cell culture to provide more physiologically relevant information and more accurate data in vivo tests has led 3D cell culture systems to become acceptable in comparison to 2D Cell culture. Many factors drive the market of 3D cell culture across the world such as an advanced technique in organ and tissue regeneration, provide drug toxicology screening and many more.

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The global 3D cell culture market has been identified as one of the fastest growing industries, owing to the varying applications of 3D cell culture in biotech and pharmaceutical industry and rising prevalence of cancer worldwide, rising approval from government bodies, and growing awareness Increasing incidence of cancer and rising demand for organs transplantation due to increasing prevalence of organ failures has majorly influenced the growth of the market.

The global 3D cell culture market is expected to grow at a CAGR of 25.50% during the forecast period 2017–2023.

Segmentation                                                                                                                

The global 3D cell culture market is segmented on the basis of technique, product, application, and end-user. On the basic technique, it is segmented into Scaffolds Based 3D Cell Culture and Scaffold-Free 3D Cell Culture.  On the basis of the product, it is segmented into Consumables and Instruments. On the basis of the application, it is segmented into cancer research, stem cell research, drug discovery, Tissue Screening & Engineering, Regenerative Medicine and others. On the basis of the end users, it is segmented into Pharmaceutical & Biotechnology Companies, Contract Research Organizations, Research & Academic Laboratories and others.

Key Findings

• The global 3D cell culture market was USD 725.15 million in 2016
• Consumables are the largest segment, by product which is projected to grow at a CAGR of 25.88% during the forecast period from 2017–2023
• Drug discovery is the largest segment, by application for the global 3D cell culture and expected to grow at a rate of CAGR 25.75% during the forecast period
• The Pharmaceutical & Biotechnology Companies segment and is expected grow with the CAGR of 26.13% for the forecast period.

Regional Analysis

Global 3D cell culture, on the basis of region, the market is divided into the Americas, Europe, Asia Pacific and the Middle East & Africa. The Americas accounted for the largest market share of for global 3D cell culture market. This large share is majorly attributed due to the presence of major manufacturers, high rate of cancer among the population, rising need for organ donation, and various others. Europe accounts for the second largest market share, whereas Asia Pacific is expected to grow at the fastest rate with 26.17% CAGR for the forecast period. With lots of opportunity and continuously growing economies, the region is expected to be the fastest growing segment. Factors such as recent healthcare developments, improving economies, high aging population, and increased healthcare spending are influencing the growth of the market. The Middle East & Africa with less economic developments and extremely low income accounted for the least market share in 2016 but is expected to grow in coming future.

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Cowden Syndrome Market 2020 Analysis, Industry Size, Share Leaders, Current Status by Major vendors and Trends by Forecast to 2027

 Cowden syndrome is part of the PTEN hamartoma tumor syndrome. Cowden syndrome is characterized by a high risk of both benign and cancerous tumors of the breast, thyroid, endometrium, colorectal, kidney, and skin. The global Cowden syndrome market is expecting a healthy growth in the coming future. The global market is majorly driven by increasing Cowden syndrome patients across the globe. Additionally, increasing smoking population and rising consumption of alcohol have spurred the growth of the market. However, long time for approval and side effects of the treatment may hinder the growth of the market.

The global Cowden syndrome market is expected to grow at a CAGR of 6.7% during the forecast period 2017-2023.

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Key Players

Some of key the players in the market are Amgen, Inc. (U.S.), Eli Lilly and Company (U.S.), AstraZeneca Plc. (U.K.), Bristol-Myers Squibb Company (U.S.), Sanofi (France), AbbVie Inc. (U.S.), Spectrum Pharmaceuticals Inc. (U.S.), Novartis AG (Switzerland), GlaxoSmithKline Plc. (U.K.), Bayer AG (Germany), Takeda Pharmaceuticals (Japan), Pfizer, Inc. (U.S.), Merck & Co., Inc. (U.S.), F. Hoffmann-La Roche Ltd. (Switzerland), Janssen Biotech, Inc. (U.S.), Immunomedics (U.S.), and Oncomed Pharmaceuticals (U.S.)

Segmentation

The global Cowden syndrome market is segmented on the basis of site, treatment and end users.

On the basis of the site, the market is segmented into the breast, thyroid, endometrium (uterus), colorectal, kidney, skin (melanoma), and others.

On the basis of the treatment, the market is categorized into genetic testing, chemotherapy, surgery & radiation therapy, targeted therapy, hormone therapy, biologic therapy, and other. The chemotherapy is further segmented into anthracyclines, taxanes, antimetabolites, and alkylating agents. The targeted therapy is sub-segmented with monoclonal antibodies and tyrosine kinase inhibitors. Hormone therapy is further segmented into selective estrogen-receptor modulators (SERMs), aromatase inhibitors, and others.

On the basis of end users, the market is segmented into hospital & clinics, ambulatory care centers, and others.

Regional Analysis

The Americas dominate the global Cowden syndrome market owing to the increasing prevalence of people suffering from Cowden syndrome and cancer. Additionally, high healthcare expenditure, well-developed technology, and strong government support for research & development have fuelled the growth of the Americas Cowden syndrome market. Presence of the leading players and increasing availability of funds in this region are likely to support the growth in the coming future.

On the other hand, the Middle East & Africa hold the least share of the market due to limited availability of funds and availability of medical facilities, and poor political conditions in Africa. The Middle East holds the major share in the Middle East & Africa Cowden syndrome market. Kuwait, Qatar, Oman, and South Arabia holds the major share of the Middle East market. However, the African region is expecting a healthy growth due to the presence of a huge opportunity for the development of the market.

And The Europe accounts for the second largest Cowden syndrome market, which is followed by the Asia Pacific. Availability of the funds for research & development and strong government support have driven the market growth. The Asia Pacific is the fastest growing Cowden syndrome market owing to the increasing prevalence of cancer, rapidly developing the economy and increasing government support. India and China are expected to lead the market in this region.

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Research report explores the Protein Assays Market for the forecast period, 2020-2027

 Protein assays are utilized in life science research to detect the presence of protein in a sample. There are various assays available in the market differing from each other on the basis of sensitivity, principle and methodology. The macro factors such as sample size, amount, interfering agents and reproducibility are also responsible for its quantification. Protein assays rely mostly on color change i.e. colorimetric assay and use of standard protein such as immunoglobulin G (IgG) or bovine serum albumin (BSA). Protein quantification is the most important step before separation and analysis by electrophoresis or chromatography or any other immunochemical techniques.

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The use of protein assays for early diagnosis of diseases such as cancer and HIV may significantly reduce the morbidity and mortality of the disease. These assays are cost effective, facile and reproducible. Commonly used protein assay are Bradford, Lowry, BCA, and UV spectroscopic protein assays. Thus, use of assay in disease diagnosis, drug discovery and development encourages the biotechnology and pharmaceutical industry to invest in R&D, which fuels the demand of protein assays market.

Several new biomarker identification systems are launched by the key players which grants various opportunities for the global protein assay market. For instance, in June 2017, Gyros Protein Technologies AB launched a new version of its anti-drug antibody (ADA) solution for the immunogenicity market. This solution enables customers to automatically run the assays in a time-efficient manner using small volumes of patient samples and reagents, and shorten run-times.

According to a publication by Pharmaceuticals Research and Manufacturers of America (PhRMA), the organizations spent approximately .8 billion on R&D in 2015 accounted for the largest part of all the biopharmaceutical R&D spending in the U.S. However, high cost of multiplex assay hardware is limiting the growth of global protein assay market.

The global protein assays market is expected to grow at a CAGR of approximately 10.8% during the forecast period 2017-2023.

Segmentation

The protein assays is segmented on the basis of type, application, product, technology and end-users.

On the basis of type, the market is segmented into copper-ion-based assays, test strip-based assays, dye-binding assays, and others

On the basis of application, market is segmented into diagnosis, drug discovery, protein purification and others

On the basis of product market is segmented into reagents & kits, instruments and others

On the basis of technology, market is segmented into colorimetric-based protein assays, fluorescence-based protein assays, and absorbance-based protein assays

On the basis of end-user, the market is segmented into hospitals & diagnostic centers, academic institutes, pharmaceutical & biotechnology companies and others.

Regional Analysis

The global protein assays market consists of countries namely America, Europe, Asia Pacific, and the Middle East.

North America is projected to hold the largest share of the global protein assay market due to presence of superior research and development base, strong regional economics, and greater emphasis on disease prevention and wellness by governments.

The European protein assay market is expected to witness rapid growth owing to the high investment in various private and government funded research and development programs in the region and increased spending on pharmaceutical and biotechnology industry development.

Countries such as China, Japan, and India in Asia Pacific are also poised to be promising markets for protein assay in the near future. The healthcare expenditure in Asia increased due to an extension of state health care programs and the increasing affluence of the population. India is anticipated to witness an expansion in spending due to a government resolution to enhance healthcare services. Moreover, China and South Korea are striving to develop their biotechnology sector for diagnosis purpose. China’s efforts to develop its biotech sector has shown good results in sectors such as vaccines and biological products and the same can be expected in the protein assays industry. However, low research and development (R&D) yields, high infrastructure cost, stringent regulatory framework, and lack of trained resources are some of the restraints of the protein assay market.

The Middle East region is expected to grow at a faster rate due to the factors such as the extensive development of health care infrastructure and growing emphasis on research and development in the health care sector.

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Hypotonia Market Dynamics, Segments and Supply Demand 2020-2027

 Hypotonia is also known as floppy baby syndrome, or weakness of muscles and lack of muscle tone.   There are two main types of hypotonia – Acquired hypotonia in which hypotonia develops after birth as the result of an underlying medical condition, injury or trauma; and congenital hypotonia in which hypotonia is present at birth. Hypotonia is a symptom rather than a condition. Major causes of hypotonia can either be neurological or non-neurological.

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Hypotonia is characterized with diminished muscle tone. The infant or child with hypotonic cerebral palsy appears floppy like a rag doll, hence the name. Hypotonic cerebral palsy is the result of an injury or malformation at an earlier brain developmental stage than that which causes spastic or choreoathetoid cerebral palsy. There are various causes of cerebral palsy which includes brain injury or brain malformation that occurs while the brain is developing i.e before, during, or after birth. As a result of the brain damage, during brain development, a child’s muscle control, muscle coordination, muscle tone, reflex, posture and balance can be affected.

Neurological problems present at birth which affect a child’s movement and co-ordination of brain and spinal cord injury including bleeding in the brain.

According to the World Health Organization estimates, neurological disorders are responsible for 4.5%-11% of all illnesses in the world including low or high income economies. This is far higher as compared to the number of respiratory ailments, gastrointestinal disorders, or cancers, and the burden is expected to increase further over the coming years.

However, limited availability of facilities and higher treatment cost may hamper the market growth during the forecast period.

The global hypotonia market is expected to grow at a CAGR of ~5.8% during the forecast period 2017-2023. 

Intended Audience

• Pharmaceutical and Biotechnological Companies
• Research and Development (R&D) Companies
• Ambulatory Care Centers
• Academic Institutes and Universities
• Market Research and Consulting Service Providers
• Potential Investors 

Segmentations

The global hypotonia market is segmented on the basis of types, diagnosis, treatment, and end user.

On the basis of the type, it is segmented into acquired hypotonia and congenital hypotonia.  

On the basis of diagnosis it is segmented into physical examination, blood tests, muscle biopsy, assessment of cerebrospinal fluid, computerized tomography or CT scan or magnetic resonance imaging (MRI) scan, electroencephalogram, electromyography, metabolic panel tests, assessment of thyroid hormone, nerve conduction velocity, genetic testing, and others.

On the basis of treatment, it is segmented into physiotherapy, occupational therapy, speech and language therapy, drugs, and others. Drugs is further segmented into neostigmine, physostigmine, and others.

On the basis of the end user, it is segmented into hospitals & clinics, research laboratories and others.

Regional Analysis

The Americas dominate the global hypotonia market owing to well-developed technology, increasing patient population, high health care spending, and increasing government support for research & development. Furthermore, increased R&D activities and the concentration of major companies have fuelled the growth of the market in this region.

Europe holds second position in the global hypotonia market owing to government support for research & development and availability of funds for research. This is expected to continue to drive the European market over the forecasted period. For instance, developed economies of the region such countries such as Germany and France are increasing investment in the healthcare domain and are focusing more on hospital infrastructure.    

Asia Pacific is the fastest growing hypotonia market owing to the presence of rapidly developing healthcare technology, huge patient population, and high healthcare expenditure. Moreover, increasing patient population in countries like India and South Korea are likely to emerge as the fastest growing market across the globe. Furthermore, increasing demand for quality devices in the healthcare is projected to lead the use of advanced equipment, which, in turn, may increase the market growth in this region.

On the other hand, the Middle East & Africa holds the least share of the market owing to less availability of funds, limited medical facilities, and deprived political conditions in Africa.

Key Players

Some of key the players in the market are LivaNova PLC (U.K), EnteroMedics Inc. (U.S.), ElectroCore Medical LLC (U.S.), Boston Scientific Corporation (U.S.), Cyberonics, Inc. (U.S.), NeuroMetrix, Inc.(U.S.), ImThera Medical (U.S.), and Inspire Medical Systems, Inc.(U.S.), and others.

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